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Comparative efficacy and safety of intra-articular analgesics after knee arthroscopy: a Bayesian network meta-analysis protocol
  1. Yuchen He1,
  2. Hongyi He1,
  3. Dong-Xing Xie1,
  4. Xiaoxiao Li2,
  5. Yilun Wang1
  1. 1Orthopaedics, Xiangya Hospital Central South University, Changsha, China
  2. 2Hunan Key Laboratory of Joint Degeneration and Injury, Changsha, Hunan, China
  1. Correspondence to Dr Yilun Wang; yilun_Wang{at}


Introduction Most of the patients who received arthroscopic knee surgery will suffer moderate to severe pain, which can delay the rehabilitation process and increase the risk of postoperative complications. Therefore, seeking a safe and effective postoperative analgesia is necessary for promoting the application of arthroscopic surgery. This protocol aims to detail a planned systematic review and meta-analysis on the comparative efficacy and safety of single-dose intra-articular injection of analgesics for pain relief after knee arthroscopy.

Method and analysis PubMed, Embase, Web of Science and Cochrane Library will be searched from inception to 1 June 2020 to retrieve randomised controlled trials (RCTs) that compared the commonly used single-dose intra-articular analgesics (ie, morphine; bupivacaine (including levobupivacaine); ropivacaine and magnesium alone or in combination) with placebo or between each other for postoperative pain relief among patients who had received knee arthroscopy. The primary outcome is pain intensity at 2-hour and 24-hour postoperatively; the secondary outcomes include side effects (eg, knee effusion, nausea, vomiting and flushing), the number of patients requiring supplementary analgesia and the time to first analgesic request. The methodological quality of the included RCTs will be assessed based on the Cochrane risk of bias table. The Bayesian network meta-analysis will be conducted using WinBUGS V.1.4.3.

Ethics and dissemination Since no private or confidential patient data will be contained in the reporting, approval from an ethics committee is not required. Our study raises no ethical issue, and the results will be published in a peer-reviewed journal.

PROSPERO registration number CRD42019130876.

  • anaesthesia in orthopaedics
  • pain management
  • orthopaedic & trauma surgery
  • knee

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  • Contributors YH and YW will conceive the study methods, perform database search, article selection, data extraction and statistical analysis, and draft the manuscript. XL, HH and DX will support with the data extraction process. All authors will read and approve the final manuscript.

  • Funding This work will be supported by the National Natural Science Foundation of China (81772413, 81601941, 81702207, 81702206, 81930071), the National Key Research and Development Program of China (2018YFB1105705), the Scientific Research Project of Science and Technology Office of Hunan Province (2017TP1005), the Key Research and Development Program of Hunan Province (2018SK2070), the Young Investigator Grant of Xiangya Hospital, Central South University (2016Q03, 2016Q06, 2017Q10), the Xiangya Clinical Big Data System Construction Project of Central South University (45), the Clinical Scientific Research Foundation of Xiangya Hospital, Central South University (2015L03), the Postdoctoral Science Foundation of Central South University (182130), and the Natural Science Foundation of Hunan Province (2017JJ3491, 2017JJ3492, 2018JJ3825, 2019JJ50965).

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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