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Abstract
Objectives In the past decade, China has been characterised by large-scale urbanisation as well as rapid economic growth. The aim of this study was to further investigate the prevalence of hyperuricaemia (HUA) in an Eastern Chinese population.
Design Cross-sectional study.
Setting Survey of Prevalence in East China of Metabolic Diseases and Risk Factors China study.
Participants In this study, 12 770 residents from 22 sites in Eastern China were recruited. Finally, 9225 subjects were included.
Main outcome measures The serum levels of uric acid (UA), fasting plasma glucose (FPG), glycated haemoglobin and other metabolic parameters were tested. Waist circumference, weight, height and blood pressure were also measured. Questionnaires regarding smoking, drinking, education were collected from the subjects. HUA was defined as serum UA >420 µmol/L for men and >360 µmol/L for women.
Results The prevalence of HUA in this Eastern Chinese population was 11.3% (9.9, 12.7) overall, 20.7% (17.7, 23.7) in men and 5.6% (4.3, 6.7) in women. The prevalence of HUA in urban subjects was higher than that in rural subjects (12.9 vs 10.8%, p<0.01). The prevalence of HUA was negatively and positively associated with age in men and women, respectively. Residents with high body mass index levels had a higher prevalence of HUA. In the logistic regression analysis, male sex, urban residency, total cholesterol, triglyceride, overweight, obesity, systolic blood pressure and low economic status were independently correlated with HUA.
Conclusions The estimated prevalence of HUA in this Eastern Chinese population was 11.3% (9.9, 12.7) overall and 20.7% (17.7, 23.7) and 5.6% (4.3, 6.7) in men and women, respectively. HUA has gradually become an important public health issue in China.
Trial registration number ChiCTR-ECS-14005052.
- general endocrinology
- epidemiology
- diabetes & endocrinology
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Footnotes
Contributors YL and BH designed and supervised this investigation. BH performed this investigation. YiC, CZ and YinC contributed to the data collection. NW and QL provided technical or material support. All authors read and approved the final manuscript.
Funding This study was supported by National Natural Science Foundation of China (91857117, 81670717); Science and Technology Commission of Shanghai Municipality (19140902400, 18410722300); the Major Science and Technology Innovation Program of Shanghai Municipal Education Commission (2019-01-07-00-01-E00059); Commission of Health and Family Planning of Pudong District (PWZxq2017-17); Municipal Human Resources Development Program for Outstanding Young Talents in Medical and Health Sciences in Shanghai (2017YQ053); Shanghai JiaoTong University School of Medicine (19XJ11007).
Disclaimer The funders played no role in the design or conduct of the study, collection, management, analysis, or interpretation of data or in the preparation, review, or approval of the article.
Competing interests None declared.
Patient consent for publication Not required.
Ethics approval This study was approved by the ethics committee of the Shanghai Ninth People’s Hospital affiliated with Shanghai Jiaotong University School of Medicine.
Provenance and peer review Not commissioned; externally peer reviewed.
Data availability statement Data are available on reasonable request to corresponding author.