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Cohort profile
The Copenhagen Primary Care Laboratory Pregnancy (CopPreg) database
  1. Janet Janbek1,2,
  2. Margit Kriegbaum2,
  3. Mia Klinten Grand2,3,
  4. Ina Olmer Specht4,
  5. Bent Struer Lind5,
  6. Christen Lykkegaard Andersen2,6,
  7. Berit Lilienthal Heitmann2,4
  1. 1Danish Dementia Research Centre, Department of Neurology, The Neuroscience Centre, Rigshospitalet, Copenhagen, Denmark
  2. 2Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark
  3. 3Section of Biostatistics, Department of Public Health, University of Copenhagen, Copenhagen, Denmark
  4. 4Research Unit for Dietary Studies, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark
  5. 5Department of Clinical Biochemistry, Copenhagen University Hospital, Hvidovre, Denmark
  6. 6Department of Hematology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
  1. Correspondence to Dr Berit Lilienthal Heitmann; Berit.Lilienthal.Heitmann{at}


Purpose The Copenhagen Primary Care Laboratory Pregnancy (CopPreg) database was established based on data from The Danish Medical Birth Register and the Copenhagen Primary Care Laboratory (CopLab) database. The aim was to provide a biomedical and epidemiological data resource for research in early disease programming (eg, parental clinical biomarker levels and pregnancy/ birth outcomes or long-term health in the offspring).

Participants The cohort consisted in total of 203 608 women (with 340 891 pregnancies) who gave birth to 348 248 children and with 200 590 related fathers. In this paper, we focused on women and fathers who had clinical test requisitions prior to and during pregnancy, and on all children. Thus, the cohort in focus consisted of 203 054 pregnancies with requisitions on 147 045 pregnant women, 39 815 fathers with requisitions during periconception and 65 315 children with requisitions.

Findings to date In addition to information on pregnancy and birth health status and general socio-demographic data, over 2.2 million clinically relevant test results were available for pregnancies with requisitions, over 1.5 million for children and over 600 000 test results were available for the fathers with requisitions during periconception. These were ordered by general practitioners in the primary care setting only and included general blood tests, nutritional biomarkers (macronutrients and micronutrients) and hormone tests. Information on tests related to infections, allergies, heart and lung function and sperm analyses (fathers) were also available.

Future plans The CopPreg database provides ready to use and valid data from already collected, objectively measured and analysed clinical tests. With several research projects planned, we further invite national and international researchers to use this vast data resource. In a coming paper, we will explore and discuss the indication bias in our cohort.

  • pregnancy
  • parental
  • biomarkers
  • clinical tests
  • early disease programming
  • offspring health

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  • CLA and BLH shared the last authorship.

  • CLA and BLH are joint senior authors.

  • Contributors JJ, BLH and CLA were responsible for the establishment of the database by obtaining all necessary permissions from relevant data authorities and for conducting the merge of data. MK and JJ were responsible for the data management and providing descriptive statistics of the cohort. BSL was responsible for all clinical tests data content of the database. MKG contributed with statistical knowledge regarding biasses in the database. JJ drafted the manuscript and MK, MKG, IOS, BSL, CLA and BLH together with JJ revised the manuscript with equal contributions to the intellectual content and manuscript format. All authors were responsible for the final version of the manuscript. CLA and BLH share last authorship and they have equally contributed to this work.

  • Funding The development of the CopLab database, from which the CopPreg database was derived, was supported by The Research Unit for General Practice and Section of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark. Furthermore, the establishment of the CopPreg database was supported by the Lundbeck and Lilly and Herbert Hansens Foundations. The foundations had no role in the design, conduction or reporting of the database.

  • Competing interests None declared.

  • Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting or dissemination plans of this research.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available upon reasonable request. Data from the CopPreg database are stored securely and in an anonymised form at the Research Unit for General Practice, Section of General Practice at the Department of Public Health, University of Copenhagen. Data access and utility is detailed in the manuscript. Researchers are invited to contact the corresponding author upon interest to use data from the CopPreg database.

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