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Abstract
Introduction Oesophagogastric cancers carry a high mortality, economic burden and rising incidence. There is a need to monitor and improve care for this disease. Pathologic information is a cornerstone of cancer diagnosis, treatment and prognosis. Few population-based studies combine pathology information and clinical outcomes. The objective of this study is to develop a clinical and pathological database of oesophagogastric cancers to study practice patterns, resource utilisation and clinical outcomes.
Methods and analysis The Population Registry of Esophageal and Stomach Tumours in Ontario (PRESTO) will include all patients with oesophagogastric cancer diagnosed from 2002 onwards within the province of Ontario. We estimate that the sample over the first 14 years of the study will include 26 000 patients. Pathologic information from diagnostic procedures, endomucosal resection specimens and surgical resection specimens is being abstracted into a purpose-built database. Pathology information will be linked to administrative data, which capture baseline demographics, patient-reported symptoms, physician billings, hospital visits, hospital characteristics, geography and vital statistics. The registry will be updated prospectively.
Ethics and dissemination Ethics approval for this study was obtained from the Sunnybrook Health Sciences Centre Research Ethics Board. The PRESTO database will enable the study of oesophagogastric cancer in Ontario under six themes of inquiry: treatment, surgical outcomes, pathology, survival, health system and resource utilisation and cost. This information will be a valuable addition to the global efforts to understand ways to optimise care for these diseases.
- pathology
- oncology
- surgery
- oesophageal disease
- gastrointestinal tumours
- gastrointestinal tumours
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Collaborators PRESTO Study Investigators: Vaibhav Gupta, Division of General Surgery, Department of Surgery and Institute of Health Policy, Management, and Evaluation, University of Toronto, Canada. Jordan Levy, Division of General Surgery, Department of Surgery and Institute of Health Policy, Management, and Evaluation, University of Toronto, Canada. Catherine Allen-Ayodabo, Evaluative Clinical Sciences, Sunnybrook Research Institute, Toronto, Canada. Elmira Amirazodi, Evaluative Clinical Sciences, Sunnybrook Research Institute, Toronto, Canada. Yunni Jeong, Division of General Surgery, Department of Surgery and Institute of Health Policy, Management, and Evaluation, University of Toronto, Canada. Laura E. Davis, Evaluative Clinical Sciences, Sunnybrook Research Institute, Toronto, Canada. Qing Li, MSc. Institute for Clinical Evaluative Sciences, Toronto, Canada. James R. Conner, Department of Laboratory Medicine and Pathobiology, University of Toronto; Mount Sinai Hospital, Toronto, Canada. Eugene Hsieh, Department of Laboratory Medicine and Pathobiology, University of Toronto; Sunnybrook Health Sciences Centre, Toronto, Canada. Alyson L. Mahar, Manitoba Centre for Health Policy and Department of Community Health Sciences, University of Manitoba, Canada. Jolie Ringash, MD, MSc. Department of Radiation Oncology and Institute of Health Policy, Management, and Evaluation, University of Toronto, Canada. Elena Elimova, Division of Medical Oncology, Department of Medicine, University of Toronto; Princess Margaret Cancer Centre, Toronto, Canada. Rinku Sutradhar, PhD. Institute for Clinical Evaluative Sciences and Institute of Health Policy, Management, and Evaluation, University of Toronto, Canada. Biniam Kidane, Section of Thoracic Surgery, Department of Surgery, University of Manitoba. Gail E. Darling, Department of Surgery and Institute of Health Policy, Management, and Evaluation, University of Toronto; Toronto General Hospital/University Health Network, Toronto, Canada. Natalie G. Coburn, Division of General Surgery, Department of Surgery and Institute of Health Policy, Management, and Evaluation, University of Toronto; Sunnybrook Health Sciences Centre, Toronto, Canada.
Contributors VG and NGC designed the study with input from all authors. VG, CA-A, EA, JL, LED, ALM, QL and NGC acquired the data. QL analysed the data, and it was interpreted by VG, JL and NGC with input from all authors. VG and JL drafted the manuscript and all authors revised it critically. All authors and PRESTO investigators approved the final version for publication and are accountable for all aspects of the work.
Funding This study is supported by the Sherif and MaryLou Hanna Chair in Surgical Oncology at Sunnybrook Health Sciences Centre.
Competing interests NGC and GED receive salary support from Ontario Health-Cancer Care Ontario.
Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.
Patient consent for publication Not required.
Provenance and peer review Not commissioned; externally peer reviewed.