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Hughes-McCormack et al. investigated live birth, death rates and childhood hospitalisations in people with Down syndrome (1). Regarding childhood hospitalisations, adjusted hazard ratios (HRs) (95% confidence intervals [CIs]) of people with Down syndrome for hospital admission, readmission, and emergency admission were 1.84 (1.68, 2.01), 2.56 (2.08, 3.14), and 2.87 (2.61, 3.15), respectively. In addition, people with Down syndrome presented longer lengths of stays than controls. I have a query about their study.
Fitzgerald et al. described patterns of hospitalisations for children and young people with Down syndrome (2). Children with Down syndrome were at increased risk of morbidity for varied causes. Rate ratio (RR) (95% CI) of children with Down syndrome for overall hospitalisations was 5.2 (4.3, 6.2) by setting Silva data (3) as a control. I think that HR or RR would be changed according to control data, and hospitalisation rate would be changed with time. In addition, socioeconomic status would also be closely related to hospitalisation rate. Regarding the improved prognosis of people with Down syndrome, comprehensive analysis is needed by compiling information on medication and other social supporting systems.
1. Hughes-McCormack LA, McGowan R, Pell JP, et al. Birth incidence, deaths and hospitalisations of children and young people with Down syndrome, 1990-2015: birth cohort study. BMJ Open. 2020;10(4):e033770. Published 2020 Apr 1. d...
1. Hughes-McCormack LA, McGowan R, Pell JP, et al. Birth incidence, deaths and hospitalisations of children and young people with Down syndrome, 1990-2015: birth cohort study. BMJ Open. 2020;10(4):e033770. Published 2020 Apr 1. doi:10.1136/bmjopen-2019-033770
2. Fitzgerald P, Leonard H, Pikora TJ, Bourke J, Hammond G. Hospital admissions in children with down syndrome: experience of a population-based cohort followed from birth. PLoS One. 2013;8(8):e70401. Published 2013 Aug 13. doi:10.1371/journal.pone.0070401
3. Silva D, Palandri G, Bower C, Gill L, Codde J, et al. Specific child and adolescent health problems in Western Australia. East Perth, Western Australia: Health Department of Western Australia and TVW Telethon Institute for Child Health Research, 1999.