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Original research
Healthcare professionals knowledge, attitude and practice of adverse drug reactions reporting in Ethiopia: a cross-sectional study
  1. Kidu Gidey,
  2. Mohammedamin Seifu,
  3. Berhane Yohannes Hailu,
  4. Solomon Weldegebreal Asgedom,
  5. Yirga Legesse Niriayo
  1. Department of Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Mekelle University, Mekelle, Ethiopia
  1. Correspondence to Kidu Gidey; kidupharm{at}


Objective This study aimed to assess the knowledge, attitude and practice of adverse drug reactions (ADRs) reporting and identify factors associated with ADRs reporting among healthcare professionals (HCPs) working in Tigray region, Ethiopia.

Materials and methods A cross-sectional study was conducted between January and March of 2019 in a tertiary care hospital in Tigray region, Ethiopia. A self-administered, pretested questionnaire was administered to HCPs. Data were summarised using descriptive statistics. Logistic regression analysis was used to identify factors associated with poor ADRs reporting practices.

Results In total, 362 questionnaires were distributed, and the response rate was 84.8% (n=307). Of all respondents, 190 (61.9%) were nurses, 63 (20.5%) were pharmacist and 54 (17.6%) were physicians. About 58.3% of HCPs had poor knowledge of ADRs reporting. The majority of the respondents had a positive attitude (59.9%), and only a few (32.1%) respondents have good ADRs reporting practices. Poor knowledge (adjusted OR (AOR)=2.63, 95% CI: 1.26 to 5.45) and lack of training on ADRs reporting (AOR=7.31, 95% CI: 3.42 to 15.62) were both negatively associated with ADRs reporting practice, whereas higher work experience (≥10 years) (AOR=0.36, 95% CI: 0.13 to 0.97) was positively associated with ADRs reporting practice.

Conclusions The majority of HCPs had poor knowledge and practice, but a positive attitude towards ADRs reporting. Poor knowledge, less work experience and lack of training were associated with poor ADRs reporting practice. Hence, strategies to improve the knowledge and practice of ADRs reporting should be implemented, particularly for untrained and less experienced HCPs.

  • adverse drug reaction
  • healthcare professionals
  • knowledge
  • practice

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  • Contributors KG and MS conceived the study and drafted the manuscript and contributed to data entry, data analysis, draft manuscript and final proof reading. BYH, SWA and YLN participated in study design, data analysis and in the process of manuscript writing. All authors approved the final manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval The ethical approval and clearance were obtained from the Ethics Review Committee of the School of Pharmacy, College of Health Sciences, Mekelle University (reference number: CHS/161/pharm-11). In addition, a brief description of the objective of the study was provided for all the participants to avoid ambiguity and misunderstanding. The data collection process was initiated after the willingness of the health professionals was requested and formal written consent was obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement The dataset of this study is available from the corresponding author upon request.