Introduction Rapid, robust and continually updated evidence synthesis is required to inform management of COVID-19 in pregnant and postpartum women and to keep pace with the emerging evidence during the pandemic.
Methods and analysis We plan to undertake a living systematic review to assess the prevalence, clinical manifestations, risk factors, rates of maternal and perinatal complications, potential for mother-to-child transmission, accuracy of diagnostic tests and effectiveness of treatment for COVID-19 in pregnant and postpartum women (including after miscarriage or abortion). We will search Medline, Embase, WHO COVID-19 database, preprint servers, the China National Knowledge Infrastructure system and Wanfang databases from 1 December 2019. We will supplement our search with studies mapped by Cochrane Fertility and Gynaecology group, Evidence for Policy and Practice Information and Co-ordinating Centre (EPPI-Centre), COVID-19 study repositories, reference lists and social media blogs. The search will be updated every week and not be restricted by language. We will include observational cohort (≥10 participants) and randomised studies reporting on prevalence of COVID-19 in pregnant and postpartum women, the rates of clinical manifestations and outcomes, risk factors in pregnant and postpartum women alone or in comparison with non-pregnant women with COVID-19 or pregnant women without COVID-19 and studies on tests and treatments for COVID-19. We will additionally include case reports and series with evidence on mother-to-child transmission of SARS-CoV-2 in utero, intrapartum or postpartum. We will appraise the quality of the included studies using appropriate tools to assess the risk of bias. At least two independent reviewers will undertake study selection, quality assessment and data extraction every 2 weeks. We will synthesise the findings using quantitative random effects meta-analysis and report OR or proportions with 95% CIs and prediction intervals. Case reports and series will be reported as qualitative narrative synthesis. Heterogeneity will be reported as I2 and τ2 statistics.
Ethics and dissemination Ethical approval is not required as this is a synthesis of primary data. Regular updates of the results will be published on a dedicated website (https://www.birmingham.ac.uk/research/who-collaborating-centre/pregcov/index.aspx) and disseminated through publications, social media and webinars.
PROSPERO registration number CRD42020178076.
- maternal medicine
- protocols & guidelines
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MY, LD, TK and SRC are joint first authors.
Contributors All authors contributed to the development of the protocol and writing of the manuscript. MY, LD, TK, SRC—wrote the first draft of the manuscript. JA, ES—designed the study. DC, SIL—reviewed the manuscript and were involved in quality assessment and data extraction. They have approved the final version of the manuscript. ACL, AD, DZ, RB—reviewed the manuscript and are involved in study selection, and they have approved the final version of the manuscript. XQ, MY, MvW, EK, EvL, LM, HK, AK, ST, JT, VB, NB, EK, CK, AT, PR-S, HP-H, OTO—reviewed the manuscript, contributing critical changes, and they have approved the final version of the manuscript. JZ reviewed the manuscript and will conduct the statistical analysis. He approved the final version of the manuscript. MB designed the study, and reviewed the manuscript and has approved the final version of the manuscript. ST conceived and designed the study and reviewed the manuscript and approved the final version of the manuscript. ST is the guarantor. All authors reviewed the manuscript, contributing critical changes and approved the final version of the manuscript.
Funding The work is partially funded by the WHO. The authors alone are responsible for the views expressed in this manuscript and they do not necessarily represent the decisions, policy or views of the funding bodies. The views of the funding bodies have not influenced the content of this manuscript.
Competing interests None declared.
Patient consent for publication Not required.
Provenance and peer review Not commissioned; externally peer reviewed.
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