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Emergency medicine
Protocol
NTNU intranasal naloxone trial (NINA-1) study protocol for a double-blind, double-dummy, non-inferiority randomised controlled trial comparing intranasal 1.4 mg to intramuscular 0.8 mg naloxone for prehospital use

Authors

  • Arne Kristian Skulberg Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, NorwayDivision of Prehospital Services, Oslo University Hospital, Oslo, Norway PubMed articlesGoogle scholar articles
  • Ida Tylleskär Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, NorwayClinic of Emergency Medicine and Prehospital Care, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway PubMed articlesGoogle scholar articles
  • Anne-Cathrine Braarud Division of Prehospital Services, Oslo University Hospital, Oslo, Norway PubMed articlesGoogle scholar articles
  • Jostein Dale Clinic of Emergency Medicine and Prehospital Care, St Olavs Hospital, Trondheim University Hospital, Trondheim, NorwayDepartment of Research and Development, Norwegian Air Ambulance Foundation, Oslo, Norway PubMed articlesGoogle scholar articles
  • Fridtjof Heyerdahl Division of Prehospital Services, Oslo University Hospital, Oslo, NorwayDepartment of Research and Development, Norwegian Air Ambulance Foundation, Oslo, Norway PubMed articlesGoogle scholar articles
  • Sindre Mellesmo Division of Prehospital Services, Oslo University Hospital, Oslo, Norway PubMed articlesGoogle scholar articles
  • Morten Valberg Oslo Centre for Biostatistics and Epidemiology, University of Oslo, Oslo, Norway PubMed articlesGoogle scholar articles
  • Ola Dale Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, NorwayDepartment of Research and Development, St Olavs University Hospital, Oslo, Norway PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Arne Kristian Skulberg; arne.skulberg{at}ntnu.no
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Citation

Skulberg AK, Tylleskär I, Braarud A, et al
NTNU intranasal naloxone trial (NINA-1) study protocol for a double-blind, double-dummy, non-inferiority randomised controlled trial comparing intranasal 1.4 mg to intramuscular 0.8 mg naloxone for prehospital use
BMJ Open 2020;10:e041556. doi: 10.1136/bmjopen-2020-041556

Publication history

  • Received June 11, 2020
  • Revised September 16, 2020
  • Accepted October 21, 2020
  • First published November 12, 2020.
Online issue publication 
October 18, 2023
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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.