Article Text
Abstract
Objectives To evaluate the association between caesarean section and migraine in a population-based register-linked cohort study.
Setting Data from the population-based Nord-Trøndelag Health Studies (HUNT2 and HUNT3) were linked to information from the Norwegian Medical Birth Registry.
Participants 65 343 participants responded to the headache questions in any of the two HUNT studies. Only those answering the headache questions in HUNT2 or 3 and had information about mode of delivery in the Norwegian Medical Birth Registry (born after 1967) were included. Our final sample consisted of 6592 women and 4602 men, aged 19–41 years.
Outcomes ORs for migraine given caesarean section. Analyses were performed in multivariate logistic regression models.
Results After adjusting for sex, age and fetal growth restriction, delivery by caesarean section was not associated with migraine later in life (OR 0.86, 95% CI 0.64 to 1.15). Delivery by caesarean section was associated with a reduced OR of non-migrainous headache (OR 0.77, 95% CI 0.60 to 0.99).
Conclusion No association was found between caesarean section and migraine in this population-based register-linked study.
- epidemiology
- migraine
- general medicine (see internal medicine)
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Footnotes
Contributors ESK had the original idea for the study and together with BSW, SB and J-AZ planned the overall design. ESK prepared the initial draft and was the main author of the present manuscript. SB conducted the data analyses. All authors planned the statistics methodology and were involved in all analyses. All authors have read, revised and approved the final manuscript.
Funding This study is supported by grants from the University of Oslo, Akershus University Hospital and Oslo University Hospital. The funding sources had no role in the design of the study; the collection, analysis and interpretation of the data; preparation of the manuscript or the decision to submit the manuscript for publication.
Competing interests None declared.
Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.
Patient consent for publication Not required.
Ethics approval Participation was based on informed, written consent, and the study was approved by the Regional Committee for Medical and Health Research (2013/1077/REK sør-øst). In addition, the HUNT Study was approved by the Norwegian Data Inspectorate.
Provenance and peer review Not commissioned; externally peer reviewed.
Data availability statement No data are available. The authors declare that the data supporting the findings of this study are available within the article.