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Uptake and effectiveness of a tailor-made online lifestyle programme targeting modifiable risk factors for dementia among middle-aged descendants of people with recently diagnosed dementia: study protocol of a cluster randomised controlled trial (Demin study)
  1. Joyce Vrijsen1,
  2. Ameen Abu-Hanna2,
  3. Els LM Maeckelberghe3,
  4. Peter Paul De Deyn4,
  5. Andrea F de Winter5,
  6. Fransje E Reesink4,
  7. Richard C Oude Voshaar6,
  8. Erik Buskens1,
  9. Sophia E de Rooij7,
  10. Nynke Smidt1
  11. On behalf of the Demin consortium
  1. 1Department of Epidemiology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands
  2. 2Department of Medical Informatics, University of Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
  3. 3Wenckebach Institute for Training and Education, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands
  4. 4Department of Neurology and Alzheimer Centre Groningen, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands
  5. 5Department of Health Sciences, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands
  6. 6Department of Psychiatry, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands
  7. 7Medical School Twente, Medical Spectrum Twente, Enschede, The Netherlands
  1. Correspondence to Joyce Vrijsen; j.vrijsen{at}umcg.nl

Abstract

Introduction Descendants of patients with dementia have a higher risk to develop dementia. This study aims to investigate the uptake and effectiveness of an online tailor-made lifestyle programme for dementia risk reduction (DRR) among middle-aged descendants of people with recently diagnosed late-onset dementia.

Methods and analysis Demin is a cluster randomised controlled trial, aiming to include 21 memory clinics of which 13 will be randomly allocated to the passive (poster and flyer in a waiting room) and 8 to the active recruitment strategy (additional personal invitation by members of the team of the memory clinic). We aim to recruit 378 participants (40–60 years) with a parent who is recently diagnosed with Alzheimer’s disease or vascular dementia at one of the participating memory clinics. All participants receive a dementia risk assessment (online questionnaire, physical examination and blood sample) and subsequently an online tailor-made lifestyle advice regarding protective (Mediterranean diet, low/moderate alcohol consumption and high cognitive activity) and risk factors (physical inactivity, smoking, loneliness, cardiovascular diseases (CVD), hypertension, high cholesterol, diabetes, obesity, renal dysfunction and depression) for dementia. The primary outcome is the difference in uptake between the two recruitment strategies. Secondary outcomes are change(s) in (1) the Lifestyle for Brain Health score, (2) individual health behaviours, (3) health beliefs and attitudes towards DRR and (4) compliance to the tailor-made lifestyle advice. Outcomes will be measured at 3, 6, 9 and 12 months after baseline. The effectiveness of this online tailor-made lifestyle programme will be evaluated by comparing Demin participants to a matched control group (lifelines cohort).

Ethics and dissemination This study has been approved by the Dutch Ministry of Health, Welfare and Sport according to the Population Screening Act. All participants have to give online informed consent using SMS-tan (transaction authentication number delivered via text message). Findings will be disseminated through peer-reviewed journals and (inter)national conferences.

Trial registration number NTR7434.

  • dementia
  • risk management
  • epidemiology
  • preventive medicine
  • public health
https://creativecommons.org/licenses/by/4.0/

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

https://doi.org/10.1136/bmjopen-2020-039439

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    Footnotes

    • Collaborators The members of the Demin consortium are: Elske Marije Abma (MD), Ameen Abu-Hanna (PhD), Erik Buskens (MD, PhD), Jürgen Claassen (MD, PhD), Peter Paul De Deyn (MD, PhD), Theo Feitsma (MD), Liesbeth Hempenius (MD, PhD), Jan Hoogmoed (MD), Ad Kamper (MD, PhD), Dineke Koek (MD, PhD), Jolijn Kragt (MD, PhD), Joep Lagro (MD, PhD), Els Lambooij (MD), Marc Langedijk (MD), Els Maeckelberghe (PhD), Francesco Mattace Raso (MD, PhD), Marieke Meinardi (MD, PhD), Richard Oude Voshaar (MD, PhD), Fransje Reesink (MD, PhD), Sophia de Rooij (MD, PhD), Antoinette Scheepmaker (MD), Nynke Smidt (PhD), Petra Spies (MD, PhD), Diana Taekema (MD, PhD), Jos Verkuyl (MD), Ralf Vingerhoets (MD), Joyce Vrijsen (MSc), Andrea de Winter (PhD).

    • Contributors JV contributed to the study concept and design, drafting of the manuscript and critical revision of the manuscript. NS and SEdR conceived the idea, were responsible for data acquisition, contributed to the study concept and design and the critical revision of the manuscript. AAH, ELMM, PPDD, AFdW, FER, RCOV and EB contributed to the study concept and design, and the critical revision of the manuscript. All authors read and approved the final manuscript.

    • Funding This study was supported by grants from the Netherlands Organisation for Health Research and Development (ZonMw), subprogram prevention program (project number: 531002008).

    • Competing interests None declared.

    • Patient consent for publication Not required.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise.