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Hospital readmission after anterior cruciate ligament reconstruction: protocol for a systematic review and meta-analysis
  1. Long Shao1,
  2. Di Wu2,
  3. Jia-Ying Li3,
  4. Xiang-Dong Wu2,4,
  5. Xi Zhou2,
  6. Gui-Xing Qiu2,
  7. Changqi Luo4,
  8. Peng-Cheng Xiao4,
  9. Jia-Cheng Liu4,
  10. Wei Huang4
  1. 1Department of Orthopaedic Surgery, Ningbo No.6 Hospital, Ningbo, Zhejiang, China
  2. 2Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
  3. 3Departments of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
  4. 4Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
  1. Correspondence to Professor Wei Huang; drhuangwei68{at}


Introduction Anterior cruciate ligament (ACL) injury is one of the most common injuries of the knee. ACL reconstruction (ACLR) has been widely performed as a safe and effective treatment for ACL injuries. As there is an increasing trend in the incidence of ACL injury, hospital readmission after ACLR has attracted renewed attention for the financial burden to both patients and the healthcare system. However, information about hospital readmission after ACLR remains fragmented. Therefore, we plan to systematically review the literature to investigate the rate of, causes and risk factors for hospital readmission after ACLR, and summarise interventions to reduce hospital readmission. This article is to provide the protocol for an upcoming systematic review and meta-analysis on this important issue.

Methods and analysis Reporting of this protocol follows the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) checklist. Electronic databases, including PubMed, Embase and the Cochrane Library, will be systematically searched from inception to June 2020. No language restrictions will be applied. Studies will be included if they reported hospital readmission or explored the associated potential causes and risk factors for hospital readmission after ACLR. The primary outcome will be the number and time frame of hospital readmission after ACLR. Secondary outcomes will be reasons for readmission, number and types of complications, risk factors for readmission and preventive measures for readmission after ACLR. Quality assessments will be performed by using the Newcastle-Ottawa Scale (NOS). If possible, study results will be summarised in a forest plot, and heterogeneity will be tested by using the Cochran’s Q and I2 statistics.

Ethics and dissemination No ethical approval is required because our study is not related to patients or animals. The results will be published in a peer-reviewed journal.

PROSPERO registration number CRD42020058624.

  • knee
  • sports medicine
  • health & safety
  • quality in health care
  • risk management

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See:

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  • LS and DW are joint first authors.

  • Contributors LS, X-DW, WH and G-XQ conceived and designed the study. LS and X-DW drafted the protocol. J-YL, DW, XZ, LS, CL, P-CX, J-CL, WH and G-XQ revised the protocol. X-DW and J-YL will search for and select eligible studies. DW and XZ will extract the data, LS will check the data. CL and P-CX will assess the risk of bias. J-CL, WH and G-XQ will perform the data synthesis. LS and X-DW act as guarantors of the protocol. All authors approved the publication of the protocol.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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