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Comparing the effectiveness and cost-effectiveness of self-management interventions in four high-priority chronic conditions in Europe (COMPAR-EU): a research protocol
  1. Marta Ballester1,2,3,
  2. Carola Orrego1,2,3,
  3. Monique Heijmans4,
  4. Pablo Alonso-Coello5,6,
  5. Matthijs Michaël Versteegh7,
  6. Dimitri Mavridis8,9,
  7. O Groene10,
  8. Kaisa Immonen11,
  9. Cordula Wagner4,
  10. Carlos Canelo-Aybar5,6,
  11. Rosa Sunol1,2,3
  12. for the COMPAR-EU consortium
    1. 1 Avedis Donabedian Research Institute (FAD), Barcelona, Spain
    2. 2 Universitat Autònoma de Barcelona (UAB), Barcelona, Spain
    3. 3 Red de investigación en servicios de salud en enfermedades crónicas (REDISSEC), Barcelona, Spain
    4. 4 Netherlands Institute for Health Services Research (NIVEL), Utrecht, The Netherlands
    5. 5 Iberoamerican Cochrane Centre, Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain
    6. 6 CIBER de Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain
    7. 7 Institute for Medical Technology Assessment, Erasmus University Rotterdam, Rotterdam, The Netherlands
    8. 8 Department of Primary Education, University of Ioannina, Ioannina, Greece
    9. 9 Sorbone Paris Cité, Universite Paris Descartes Faculte de Medecine, Paris, Île-de-France, France
    10. 10 OptiMedis AG, Hamburg, Germany
    11. 11 European Patients' Forum, Brussels, Belgium
    1. Correspondence to Marta Ballester; mballester{at}fadq.org

    Abstract

    Introduction Population ageing and increasing chronic illness burden have sparked interest in innovative care models. While self-management interventions (SMIs) are drawing increasing attention, evidence of their efficacy is mostly based on pairwise meta-analysis, generally derived from randomised controlled trials comparing interventions versus a control or no intervention. As such, relevant efficacy data for comparisons among different SMIs that can be applied to specific chronic conditions are missing. Therefore, the relevance of the available evidence for decision-making at clinical, organisational and policy levels is limited.

    Aim To identify, compare and rank the most effective and cost-effective SMIs for adults with four high-priority chronic conditions: type 2 diabetes, obesity, chronic obstructive pulmonary disease,and heart failure.

    Methods and analysis All activities will be conducted as part of the cost-effectiveness of self-management interventions in four high-priority chronic conditions in Europe(COMPAR-EU, Comparing effectiveness of self-management interventions in 4 high priority chronic diseases inEurope) Project, an European Union (EU)-funded project designed to bridge the gap between current knowledge and practice on SMIs. In the first phase of the project, we will develop and validate a taxonomy, and a Core Outcome Set for each condition. These activities will inform a series of systematic review and network meta-analysis about the effectiveness of SMIs. We will also perform a cost-effectiveness analysis of the most effective SMIs and an evaluation of contextual factors. We will finally develop tailored decision-making tools for the different relevant stakeholders.

    Ethics and dissemination Ethical approval was obtained from the local ethics committee (University Institute for Primary Care Research - IDIAP Jordi Gol). All patients and other stakeholders will provide informed consent prior to participation. This project has been funded by the EU Horizon 2020 research and innovation programme (grant agreement no. 754936). Results will be of interest to relevant stakeholder groups (patients, professionals, managers, policymakers and industry), and will be disseminated in a tailored multi-pronged approach that will include deployment of an interactive platform.

    • protocols & guidelines
    • public health
    • qualitative research
    • statistics & research methods
    • health economics
    https://creativecommons.org/licenses/by/4.0/

    This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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    Footnotes

    • Twitter @Inst_Donabeidan

    • Collaborators The COMPAR-EU group: Ana Isabel González (Avedis Donabedian Research Institute (FAD) and, Red de investigación en servicios de salud en enfermedades crónicas (REDISSEC), Aretj-Angeliki Veroniki (University of Ioannina, Department of Primary Education), Claudia Valli (Iberoamerican Cochrane Centre – Biomedical Research Institute Sant Pau (IIB Sant Pau)), Claudio Alfonso Rocha Calderón (Iberoamerican Cochrane Centre – Biomedical Research Institute Sant Pau (IIB Sant Pau)), Ena Niño de Guzmán (Iberoamerican Cochrane Centre – Biomedical Research Institute Sant Pau (IIB Sant Pau)),Estela Camus (Avedis Donabedian Research Institute (FAD)), Giorgos Seitidis (University of Ioannina, Department of Primary Education), Hector Pardo-Hernandez (Iberoamerican Cochrane Centre – Biomedical Research Institute Sant Pau (IIB Sant Pau) and CIBER de Epidemiología y Salud Pública (CIBERESP)), Jany Rademakers (Netherlands Institute for Health Services Research, (NIVEL)), Jessica Beltrán (Iberoamerican Cochrane Centre – Biomedical Research Institute Sant Pau (IIB Sant Pau)), Karla Salas (Iberoamerican Cochrane Centre – Biomedical Research Institute Sant Pau (IIB Sant Pau)), Kevin Pacheco-Barrios (Avedis Donabedian Research Institute (FAD)), Lyudmil Ninov (European Patients' Forum), Maria Petropoulou (University of Ioannina, Department of Primary Education), Marieke van der Gaag (Netherlands Institute for Health Services Research, (NIVEL)), Montserrat León (Iberoamerican Cochrane Centre – Biomedical Research Institute Sant Pau (IIB Sant Pau)), Nina Adrion (OptiMedis AG), Rune Poortvliet (Netherlands Institute for Health Services Research, (NIVEL)), Stella Zevgiti (University of Ioannina, Department of Primary Education), Jessica Zafra (Avedis Donabedian Research Institute (FAD)), Valentina Strammiello (European Patients' Forum).

    • Contributors MB contributed to the design of the project and prepared the manuscript of the paper. CO, MH, PA-C, MV, DM, OG, KI, CW, CC and RS contributed to the design of the project and reviewed and contributed to the manuscript of the paper.

    • Funding This work was supported by European Union’s Horizon 2020 research and innovation programme under grant agreement No 754936.

    • Competing interests None declared.

    • Patient consent for publication Not required.

    • Provenance and peer review Not commissioned; externally peer reviewed.

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