Levofloxacin versus placebo for the treatment of latent tuberculosis among contacts of patients with multidrug-resistant tuberculosis (the VQUIN MDR trial): a protocol for a randomised controlled trial

Greg J Fox; Cam Binh Nguyen; Thu Anh Nguyen; Phuong Thuy Tran; Ben J Marais; Steve M Graham; Binh Hoa Nguyen; Kavi Velen; David W Dowdy; Paul Mason; Warwick J Britton; Marcel A Behr; Andrea Benedetti; Dick Menzies; Viet Nhung Nguyen; Guy B Marks

doi:10.1136/bmjopen-2019-033945

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Infectious diseases

Protocol

Levofloxacin versus placebo for the treatment of latent tuberculosis among contacts of patients with multidrug-resistant tuberculosis (the VQUIN MDR trial): a protocol for a randomised controlled trial

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Greg J Fox Central Clinical School, The University of Sydney Faculty of Medicine and Health, Sydney, New South Wales, Australia Woolcock Institute of Medical Research, Glebe, New South Wales, Australia PubMed articles Google scholar articles
Cam Binh Nguyen Woolcock Institute of Medical Research, Glebe, New South Wales, Australia PubMed articles Google scholar articles
Thu Anh Nguyen Woolcock Institute of Medical Research, Glebe, New South Wales, Australia PubMed articles Google scholar articles
Phuong Thuy Tran Woolcock Institute of Medical Research, Glebe, New South Wales, Australia PubMed articles Google scholar articles
Ben J Marais The University of Sydney Faculty of Medicine and Health, Sydney, New South Wales, Australia The University of Sydney Marie Bashir Institute for Infectious Diseases and Biosecurity, Sydney, New South Wales, Australia PubMed articles Google scholar articles
Steve M Graham Murdoch Childrens Research Institute, Parkville, Victoria, Australia Department of Paediatrics, The University of Melbourne, Melbourne, Victoria, Australia PubMed articles Google scholar articles
Binh Hoa Nguyen The National Lung Hospital, Hanoi, Vietnam PubMed articles Google scholar articles
Kavi Velen Woolcock Institute of Medical Research, Glebe, New South Wales, Australia The University of Sydney Faculty of Medicine and Health, Sydney, New South Wales, Australia PubMed articles Google scholar articles
David W Dowdy Department of Epidemiology, John Hopkins Bloomberg, Baltimore, Maryland, USA PubMed articles Google scholar articles
Paul Mason Taronga Institute of Science and Learning, Taronga Conservation Society, Sydney, New South Wales, Australia PubMed articles Google scholar articles
Warwick J Britton The University of Sydney Faculty of Medicine and Health, Sydney, New South Wales, Australia Tuberculosis Research Program, The Centenary Institute of Cancer Medicine and Cell Biology, Sydney, New South Wales, Australia PubMed articles Google scholar articles
Marcel A Behr Department of Medicine, McGill University, Montreal, Quebec, Canada McGill International Tuberculosis Centre, McGill University, Montreal, Quebec, Canada PubMed articles Google scholar articles
Andrea Benedetti Departments of Medicine and of Epidemiology, Biostatistics & Occupational Health, McGill University, Montreal, Quebec, Canada PubMed articles Google scholar articles
Dick Menzies McGill International Tuberculosis Centre, McGill University, Montreal, Quebec, Canada PubMed articles Google scholar articles
Viet Nhung Nguyen The National Lung Hospital, Hanoi, Vietnam PubMed articles Google scholar articles
Guy B Marks Woolcock Institute of Medical Research, Glebe, New South Wales, Australia South Western Sydney Clinical School, University of New South Wales, Sydney, New South Wales, Australia PubMed articles Google scholar articles

Correspondence to Dr Greg J Fox; greg.fox{at}sydney.edu.au

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Fox GJ, Nguyen CB, Nguyen TA, et al

BMJ Open 2020;10:e033945. doi: 10.1136/bmjopen-2019-033945

Publication history

Received August 29, 2019
Revised October 22, 2019
Accepted October 30, 2019
First published January 2, 2020.

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January 02, 2020

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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