Atopic disease, including atopic dermatitis (eczema), allergy and asthma, has increased in
frequency in recent decades 1 and now affects ∼20% of the population in the developed …

BACKGROUND: Atopic disease is a major health problem. Mutations in the filaggrin gene (FLG)
confer major susceptibility to eczema and related asthma. OBJECTIVE: We sought to …

Background Loss-of-function variants in the gene encoding filaggrin (FLG) are major
determinants of eczema. We hypothesized that weakening of the physical barrier in FLG-deficient …

The current study applies neural network (NN) modeling in forecasting lumpy demand. It is,
to the best of our knowledge, the first such study. Our study compares the performance of NN …

Anandamide (arachidonylethanolamide) and 2-arachidonoylglycerol mediate many of their
actions via either CB 1 or CB 2 cannabinoid receptor subtypes. These agonist-receptor …

BACKGROUND: Filaggrin is a key protein involved in skin barrier function. Filaggrin (FLG)
null mutations are important genetic predisposing factors for atopic disease. OBJECTIVE: To …

BACKGROUND: The specific genetic contributions to childhood asthma have been difficult
to elucidate. A recent whole-genome association study suggested that single nucleotide …

Background: The homozygous presence of the arginine-16 variant of the β 2 adrenoceptor
gene ADRB2 reverses the benefits from the regular use of short acting β 2 agonists in …

Background Atopic dermatitis (AD) is a major inflammatory condition of the skin caused by
inherited skin barrier deficiency, with mutations in the filaggrin gene predisposing to …

To understand how structurally distinct ligands regulate CB 1 receptor interactions with Gi1,
Gi2, and Gi3, we quantified the Gαi and βγ proteins that coimmunoprecipitate with the CB 1 …