Drug treatments for covid-19: living systematic review and network meta-analysis

RAC Siemieniuk, JJ Bartoszko, D Zeraatkar, E Kum… - bmj, 2020 - bmj.com
Objective To compare the effects of treatments for coronavirus disease 2019 (covid-19).
Design Living systematic review and network meta-analysis. Data sources WHO covid-19 …

Probiotics for the prevention of pediatric antibiotic‐associated diarrhea

BC Johnston, JZ Goldenberg… - Cochrane Database …, 2011 - cochranelibrary.com
Background Antibiotics alter the microbial balance within the gastrointestinal tract. Probiotics
may prevent antibiotic‐associated diarrhea (AAD) via restoration of the gut microflora …

Corticosteroid therapy for patients hospitalized with community-acquired pneumonia: a systematic review and meta-analysis

RAC Siemieniuk, MO Meade… - Annals of internal …, 2015 - acpjournals.org
Background: Community-acquired pneumonia (CAP) is common and often severe. Purpose:
To examine the effect of adjunctive corticosteroid therapy on mortality, morbidity, and …

Probiotics for the Prevention of Clostridium difficile–Associated Diarrhea: A Systematic Review and Meta-analysis

BC Johnston, SSY Ma, JZ Goldenberg… - Annals of internal …, 2012 - acpjournals.org
Background: Antibiotic treatment may disturb the resistance of gastrointestinal flora to
colonization. This may result in complications, the most serious of which is Clostridium …

Prevalence, characteristics, and publication of discontinued randomized trials

B Kasenda, E Von Elm, J You, A Blümle, Y Tomonaga… - Jama, 2014 - jamanetwork.com
Importance The discontinuation of randomized clinical trials (RCTs) raises ethical concerns
and often wastes scarce research resources. The epidemiology of discontinued RCTs …

[HTML][HTML] High-flow nasal cannula for acute hypoxemic respiratory failure in patients with COVID-19: systematic reviews of effectiveness and its risks of aerosolization …

A Agarwal, J Basmaji, F Muttalib… - Canadian Journal of …, 2020 - ncbi.nlm.nih.gov
Purpose We conducted two World Health Organization-commissioned reviews to inform use
of high-flow nasal cannula (HFNC) in patients with coronavirus disease (COVID-19). We …

Oxygen therapy for acutely ill medical patients: a clinical practice guideline

RAC Siemieniuk, DK Chu, LHY Kim, MR Güell-Rous… - Bmj, 2018 - bmj.com
Applies to: Patients with acute stroke or myocardial infarction 1 00 99 98 97 96 95 94 93 92
91 90 89 88 87 Recommendation 1 Stop oxygen therapy no higher than 96% saturation …

Antibody and cellular therapies for treatment of covid-19: a living systematic review and network meta-analysis

RAC Siemieniuk, JJ Bartoszko, JPD Martinez, E Kum… - Bmj, 2021 - bmj.com
Objective To evaluate the efficacy and safety of antiviral antibody therapies and blood
products for the treatment of novel coronavirus disease 2019 (covid-19). Design Living …

Prognosis after surgical replacement with a bioprosthetic aortic valve in patients with severe symptomatic aortic stenosis: systematic review of observational studies

F Foroutan, GH Guyatt, K O'Brien, E Bain, M Stein… - Bmj, 2016 - bmj.com
Objective To determine the frequency of survival, stroke, atrial fibrillation, structural valve
deterioration, and length of hospital stay after surgical replacement of an aortic valve (SAVR) …

Medical cannabis or cannabinoids for chronic pain: a clinical practice guideline

JW Busse, P Vankrunkelsven, L Zeng, AF Heen… - bmj, 2021 - bmj.com
Clinical question What is the role of medical cannabis or cannabinoids for people living with
chronic pain due to cancer or non-cancer causes? Current practice Chronic pain is common …