User profiles for "author:Marie-Claude Geoffroy"

Marie-Claude Geoffroy

Canada Research Chair in Youth Suicide Prevention - McGill University, Canada
Verified email at mcgill.ca
Cited by 3909

An additional role for SUMO in ubiquitin-mediated proteolysis

MC Geoffroy, RT Hay - Nature reviews Molecular cell biology, 2009 - nature.com
Although the post-translational modification of proteins with small ubiquitin-like modifier
(SUMO) has a role in many biological processes, it was thought that SUMO, unlike ubiquitin …

Role of promyelocytic leukemia protein in host antiviral defense

MC Geoffroy, MK Chelbi-Alix - Journal of Interferon & Cytokine …, 2011 - liebertpub.com
Several pathways have been implicated in the establishment of antiviral state in response to
interferon (IFN), one of which implicates the promyelocytic leukemia (PML) protein. The PML …

Daycare attendance, stress, and mental health

MC Geoffroy, SM Côté, S Parent… - The Canadian Journal …, 2006 - journals.sagepub.com
Objective: Daycare stress can be indexed by cortisol, and elevated levels of cortisol have
been implicated in the onset and development of mental health disorders. Our objective was …

RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

MH Tatham, MC Geoffroy, L Shen, A Plechanovova… - Nature cell …, 2008 - nature.com
In acute promyelocytic leukaemia (APL), the promyelocytic leukaemia (PML) protein is fused
to the retinoic acid receptor α (RAR). This disease can be treated effectively with arsenic …

Closing the gap in academic readiness and achievement: The role of early childcare

MC Geoffroy, SM Côté, CÉ Giguère… - Journal of Child …, 2010 - Wiley Online Library
Background: Socially disadvantaged children with academic difficulties at school entry are at
increased risk for poor health and psychosocial outcomes. Our objective is to test the …

Association of social support during adolescence with depression, anxiety, and suicidal ideation in young adults

S Scardera, LC Perret, I Ouellet-Morin… - JAMA network …, 2020 - jamanetwork.com
Importance Mental health problems are common during the transition from adolescence to
young adulthood. Although perceived social support and mental health problems have been …

Associations between peer victimization and suicidal ideation and suicide attempt during adolescence: results from a prospective population-based birth cohort

MC Geoffroy, M Boivin, L Arseneault, G Turecki… - Journal of the American …, 2016 - Elsevier
Objective To test whether adolescents who are victimized by peers are at heightened risk for
suicidal ideation and suicide attempt, using both cross-sectional and prospective …

A genome‐wide approach to children's aggressive behavior: The EAGLE consortium

I Pappa, B St Pourcain, K Benke… - American Journal of …, 2016 - Wiley Online Library
Individual differences in aggressive behavior emerge in early childhood and predict
persisting behavioral problems and disorders. Studies of antisocial and severe aggression …

HSP90 protein stabilizes unloaded argonaute complexes and microscopic P-bodies in human cells

M Johnston, MC Geoffroy, A Sobala… - Molecular biology of …, 2010 - Am Soc Cell Biol
Key components of the miRNA-mediated gene regulation pathway are localized in
cytoplasmic processing bodies (P-bodies). Mounting evidence suggests that the presence of …

[HTML][HTML] COVID-19 and the impacts on youth mental health: emerging evidence from longitudinal studies

N Chadi, NC Ryan, MC Geoffroy - Canadian Journal of Public Health, 2022 - Springer
Several experts have warned that the current coronavirus disease 2019 (COVID-19)
pandemic and associated confinement measures may have taken a devastating toll on …