Background Up-to-date evidence about levels and trends in disease and injury incidence,
prevalence, and years lived with disability (YLDs) is an essential input into global, regional …

Executive summary The number of older people, including those living with dementia, is
rising, as younger age mortality declines. However, the age-specific incidence of dementia …

An estimated 24 million people worldwide have dementia, the majority of whom are thought
to have Alzheimer's disease. Thus, Alzheimer's disease represents a major public health …

Background Given the projected trends in population ageing and population growth, the
number of people with dementia is expected to increase. In addition, strong evidence has …

Background 100 years after the first description, Alzheimer's disease is one of the most
disabling and burdensome health conditions worldwide. We used the Delphi consensus …

Background Measuring disease and injury burden in populations requires a composite
metric that captures both premature mortality and the prevalence and severity of ill-health …

Background Non-fatal health outcomes from diseases and injuries are a crucial
consideration in the promotion and monitoring of individual and population health. The …

Cerebral small vessel disease (SVD) is a common accompaniment of ageing. Features seen
on neuroimaging include recent small subcortical infarcts, lacunes, white matter …

Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by
previous studies; however, a large portion of the genetic risk for this disease remains …

We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease
(AD) involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 …