Neighborhood walkable urban form and C-reactive protein

Prev Med. 2013 Dec;57(6):850-4. doi: 10.1016/j.ypmed.2013.09.019. Epub 2013 Oct 3.

Abstract

Background: Walkable urban form predicts physical activity and lower body mass index, which lower C-reactive protein (CRP). However, urban form is also related to pollution, noise, social and health behavior, crowding, and other stressors, which may complement or contravene walkability effects.

Purpose: This paper assesses within-neighborhood correlation of CRP, and whether three features of walkable urban form (residential density, street connectivity, and land use mix) are associated with CRP levels.

Methods: CRP measures (n=610) and sociodemographic data come from the 2001-3 Chicago Community Adult Health Study, linked with objective built environment data.

Results: Within-neighborhood correlations of CRP are greater than those of related health measures. A one standard deviation increase in residential density predicts significantly higher log CRP (e.g. β=0.11, p<.01) in Chicago, while a one standard deviation increase in land use mix predicts significantly lower CRP (e.g. β=-0. 19, p<0.01). Street connectivity is unrelated to CRP in this highly walkable city.

Discussion: Results suggest that residential density may be a risk factor for inflammation, while greater walkability of mixed land use areas may be protective. It may be that negative aspects of density overcome the inflammatory benefits of walking.

Keywords: C-reactive protein; Density; Inflammation; Land use mix; Walkability; Walkable urban form.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • C-Reactive Protein / analysis*
  • Chicago / epidemiology
  • Environment Design / standards
  • Environment Design / statistics & numerical data*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Population Density
  • Residence Characteristics / statistics & numerical data*
  • Urban Population / statistics & numerical data
  • Walking / statistics & numerical data*
  • Young Adult

Substances

  • C-Reactive Protein