Pneumococcal diagnosis and serotypes in childhood community-acquired pneumonia

Diagn Microbiol Infect Dis. 2013 Jun;76(2):129-32. doi: 10.1016/j.diagmicrobio.2013.02.012. Epub 2013 Mar 26.

Abstract

The 7-valent pneumococcal conjugate vaccine (PCV7) was introduced routinely in the UK from September 2006 and replaced by PCV13 in 2010. In a prospective study from 2009 to 2011 of 160 children aged ≤16 years with radiologically confirmed pneumonia, likely pneumococcal infections were identified in 26%. Detection of pneumococci was improved with polymerase chain reaction compared to culture (21.6% versus 6% of children tested, P = 0.0004). Where serotyping was possible, all (n = 23) were non-PCV7 but PCV13 serotypes; 1 (43.5%), 3 (21.7%), 7A/F, and 19A (17.4% each).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Community-Acquired Infections / diagnosis*
  • Community-Acquired Infections / prevention & control
  • Female
  • Humans
  • Male
  • Pneumococcal Vaccines / administration & dosage
  • Pneumococcal Vaccines / therapeutic use
  • Pneumonia, Pneumococcal / diagnosis*
  • Pneumonia, Pneumococcal / immunology
  • Pneumonia, Pneumococcal / prevention & control
  • Polymerase Chain Reaction
  • Prospective Studies
  • Serotyping
  • Streptococcus pneumoniae / immunology
  • Streptococcus pneumoniae / isolation & purification*
  • Vaccines, Conjugate / administration & dosage
  • Vaccines, Conjugate / immunology

Substances

  • Pneumococcal Vaccines
  • Vaccines, Conjugate