Oxidative stress is potentially involved in the pathogenesis of Parkinson's disease (PD). Serum uric acid, because of its antioxidant effect, might prevent the development of this neurodegenerative disorder. Indeed, a number of epidemiologic studies have consistently reported a strong inverse association between serum uric acid and the risk of PD. The risk of PD is also lower among individuals with gout. In addition, suggestive evidence from clinical studies shows high levels of uric acid as a marker of better prognosis in PD. Future research should determine the mechanisms underlying this association. This, in turn, could be used in the development of new preventive strategies and treatments for PD.