This descriptive pilot study was conducted to determine whether health conditions and health care access differ between male and female long-haul truck drivers. Data indicated that 54% of men and 66% of women had a health care provider, but 21% of men and 35% of women had no health insurance. Male and female drivers both reported common health problems (e.g., back pain, sinus problems, hypertension, headaches, and arthritis). While working, drivers of each gender often waited until returning home to seek treatment for health problems. Approximately half of the drivers expressed dissatisfaction with health care while "on the road." Occupational and environmental health nurses could address the health needs of drivers by conducting examinations and distributing wellness information at truck stop clinics and from mobile health vans, posting health information within truck stop driver lounges, creating interactive websites with real-time health care information, attending trucker trade shows to conduct health screening, or providing health information through occupational or trade magazines and newsletters.