Is the current management of severe sepsis and septic shock really evidence based?

PLoS Med. 2006 Sep;3(9):e346. doi: 10.1371/journal.pmed.0030346.

Abstract

Vincent discusses the reasons why evidence-based medicine may be particularly difficult to apply in the management of patients with severe sepsis.

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Clinical Trials as Topic
  • Evidence-Based Medicine*
  • Fludrocortisone / therapeutic use
  • Guidelines as Topic
  • Humans
  • Multiple Organ Failure / prevention & control
  • Sepsis / diagnosis*
  • Sepsis / therapy*
  • Shock, Septic / diagnosis*
  • Shock, Septic / therapy*

Substances

  • Anti-Bacterial Agents
  • Fludrocortisone