Prospective study of high-dose chemotherapy and autologous peripheral stem cell transplantation in adult patients with advanced desmoplastic small round-cell tumour

A Bertuzzi; L Castagna; V Quagliuolo; V Ginanni; S Compasso; M Magagnoli; M Balzarotti; A Nozza; L Siracusano; I Timofeeva; B Sarina; H Soto Parra; A Santoro

doi:10.1038/sj.bjc.6601304

Prospective study of high-dose chemotherapy and autologous peripheral stem cell transplantation in adult patients with advanced desmoplastic small round-cell tumour

Br J Cancer. 2003 Oct 6;89(7):1159-61. doi: 10.1038/sj.bjc.6601304.

Authors

A Bertuzzi¹, L Castagna, V Quagliuolo, V Ginanni, S Compasso, M Magagnoli, M Balzarotti, A Nozza, L Siracusano, I Timofeeva, B Sarina, H Soto Parra, A Santoro

Affiliation

¹ Department of Medical Oncology and Hematology, Istituto Clinico Humanitas, Via Manzoni 56, Rozzano, Milan 20089, Italy.

Abstract

A total of 10 desmoplastic small round-cell tumour patients were treated by high-dose chemotherapy with stem cell support. After high-dose chemotherapy, no complete response conversion was obtained and EWS-WT1 fusion transcript detection was positive in the peripheral blood during follow-up in all patients. High-dose chemotherapy did not seem to change the results in desmoplastic small round-cell tumour.

MeSH terms

Abdominal Neoplasms / genetics
Abdominal Neoplasms / therapy*
Adolescent
Adult
Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
Carcinoma, Small Cell / genetics
Carcinoma, Small Cell / therapy*
Combined Modality Therapy
DNA Primers / chemistry
Humans
Male
Middle Aged
Oncogene Proteins, Fusion / genetics
Oncogene Proteins, Fusion / metabolism
Peripheral Blood Stem Cell Transplantation*
Prognosis
Prospective Studies
Reverse Transcriptase Polymerase Chain Reaction
Survival Rate
Transplantation, Autologous
Treatment Outcome

Substances

DNA Primers
EWS1-WT1 fusion protein, human
Oncogene Proteins, Fusion