Abstract
Beta-CIT can be used as a tracer for SPECT to visualize serotonin transporters in the human brain. We present a case of bulimia nervosa and major depressive disorder, who had been treated with up to 60 mg/d fluoxetine for several weeks. Four hours after injection of the tracer more than 40% of serotonin transporters were blocked. To our knowledge, this is the first direct documentation of the pharmacodynamic action of fluoxetine in the human brain in vivo.
Publication types
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Case Reports
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Clinical Trial
MeSH terms
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Adolescent
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Aged
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Antidepressive Agents, Second-Generation / pharmacology*
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Antidepressive Agents, Second-Generation / therapeutic use
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Brain / diagnostic imaging*
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Brain Chemistry / drug effects*
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Bulimia / diagnostic imaging
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Bulimia / drug therapy
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Carrier Proteins / metabolism*
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Depressive Disorder / diagnostic imaging
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Depressive Disorder / drug therapy
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Female
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Fluoxetine / pharmacology*
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Fluoxetine / therapeutic use
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Humans
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Image Processing, Computer-Assisted
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Male
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Membrane Glycoproteins / metabolism*
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Membrane Transport Proteins*
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Middle Aged
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Nerve Tissue Proteins / metabolism*
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Serotonin Plasma Membrane Transport Proteins
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Tomography, Emission-Computed, Single-Photon
Substances
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Antidepressive Agents, Second-Generation
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Carrier Proteins
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Membrane Glycoproteins
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Membrane Transport Proteins
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Nerve Tissue Proteins
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SLC6A4 protein, human
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Serotonin Plasma Membrane Transport Proteins
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Fluoxetine