Ticlopidine Alone Versus Ticlopidine Plus Aspirin for Preventing Recurrent Stroke

Eiichi ITO; Akira TAKAHASHI; Hiroko YAMAMOTO; Shigeki KUZUHARA; Shinichiro UCHIYAMA; Mitsuyoshi NAKAJIMA

doi:10.2169/internalmedicine.42.793

Eiichi ITO, Akira TAKAHASHI, Hiroko YAMAMOTO, Shigeki KUZUHARA, Shinichiro UCHIYAMA, Mitsuyoshi NAKAJIMA

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Keywords: stroke, secondary prevention, ticlopidine, aspirin, combination therapy

JOURNAL FREE ACCESS

2003 Volume 42 Issue 9 Pages 793-799

DOI https://doi.org/10.2169/internalmedicine.42.793

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Abstract

Objective To compare the efficacy and safety of two antiplatelet regimens, ticlopidine alone (200 mg daily) and ticlopidine (100 mg daily) plus aspirin (81 mg daily), in patients with ischemic stroke from the Tokai district of Japan.
Methods A randomized comparative study was performed from April 1992 until December 1995, with follow-up for an average of 1.59 years (maximum: 0

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