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A role of vitamin D in low-intensity chronic inflammation and insulin resistance in type 2 diabetes mellitus?

Published online by Cambridge University Press:  14 December 2007

Mario Flores
Mario Flores*
Affiliation:
Centro de Investigación en Nutrición y Salud, Instituto Nacional de Salud Publica (National Institute of Public Health), Cuernavaca, Mexico
*
Corresponding author: Dr Mario E. Flores, fax +52 777 11 22 19, email mflores@correo.insp.mx
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Abstract

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Evidence from different directions, including observational and experimental studies, points to a role of vitamin D status in low-intensity chronic inflammation and insulin resistance in type 2 diabetes mellitus (T2DM). It has been recognised that insulin resistance and low-intensity chronic inflammation are risk factors for T2DM. Thus, vitamin D status can be implicated in the aetiology of TD2M. It is suggested that the relationship between vitamin D and low-intensity chronic inflammation and insulin resistance in T2DM can be mediated in part by the immune-modulating properties of the active form of vitamin D (1-α,25-dihydroxyvitamin D3; 1,25(OH)2D3), which is able to down regulate the production of pro-inflammatory cytokines – particularly TNF-α, and IL-6. However, an association between vitamin D status and these features, which is independent of BMI, has been also reported. Non-calcaemic effects of vitamin D can be associated with health outcomes other than those traditionally attributed to the vitamin.

Keywords

Vitamin DType 2 diabetesInsulin resistanceC-reactive protein
Type
Research Article
Information
Nutrition Research Reviews , Volume 18 , Issue 2 , December 2005 , pp. 175 - 182
Copyright
Copyright © The Author 2005

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