Environmental and Occupational DisordersEighteen-month outcomes of house dust mite avoidance and dietary fatty acid modification in the childhood asthma prevention study (CAPS)☆,☆☆
Section snippets
Methods
The study hypotheses were tested in a parallel-group randomized controlled trial in which the 2 interventions were tested separately and then together through use of a factorial design. The details of the study design and recruitment procedure, which have been reported elsewhere,7, 8 are described briefly here.
Results
Fig 1 shows the trial profile.
Fifty-six participants withdrew after randomization and before the 12-month visit, and an additional 6 participants withdrew before the 18-month assessment. A total of 554 participants completed the 18-month assessment. Table I shows the characteristics of the participants and their families in each of the 4 intervention groups.
Characteristic DIet intervention House dust mite intervention Control N = 275 Active N = 279
Discussion
The early results of this study suggest that increasing omega-3 fatty acids in the diet in the first 18 months of life might have a beneficial effect on wheezing in high-risk infants. The prevalence of parental report of wheeze-ever was 9.8% lower and the prevalence of wheeze for >1 week 7.8% lower in the active diet intervention group. The prevalence of other indicators of wheeze and allergic disease, such as rhinitis, also tended to be reduced in this group. However, we found no benefit for
Acknowledgements
The CAPS Study senior investigators are Jennifer K. Peat, Guy B. Marks, Craig M. Mellis and Stephen R. Leeder. Associate investigators are Euan R. Tovey and Karen Webb. The Study Coordinator is Seema Mihrshahi. The authors wish to thank the CAPS research team involved in the study. Data have been collected by Anne Tattam, Samantha Forbes, Nicola Vukasin, Craig Wainwright, William Krause, and Natalia Knezevic. Allergen assays were performed by Carl H. Vanlaar and Sally Criss. Fatty acid and
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Supported in part by the National Health and Medical Research Council of Australia, New South Wales Health Department, The Children's Hospital at Westmead, and the Cooperative Research Centre for Asthma. Contributions of goods and services were made by Allergopharma Joachim Ganzer KG Germany, John Sands Australia, Hasbro, Refrigerated Roadways, and AstraZeneca. Goods were provided at reduced cost by Auspharm, Allersearch, Meadow Lea Foods, and Clover Corporation.
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Reprint requests: Seema Mihrshahi, MPH, Clinical Epidemiology Unit, The Children's Hospital at Westmead, Locked Bag 4001, Westmead, NSW 2145, Australia.