Issue 2, 2010
From the journal:

Molecular BioSystems

Complex genetic regulation of proteinglycosylation

Gordan Lauc,*ab   Igor Rudan,cde   Harry Campbellef  and  Pauline M. Ruddg  

* Corresponding authors

a University of Zagreb, Faculty of Pharmacy and Biochemistry, A. Kovacica 1, HR-10000 Zagreb, Croatia
E-mail: glauc@pharma.hr
Fax: +385 1 639 4400

b Genos Ltd., Glycobiology Division, Planinska 1, Zagreb, Croatia

c Gen Info Ltd., Zagreb, Croatia

d Croatian Centre for Global Health, University of Split Medical School, Split, Croatia

e Department of Public Health Sciences, The University of Edinburgh Medical School, UK

f Institute of Genetics and Molecular Medicine, The University of Edinburgh, UK

g Dublin-Oxford Glycobiology Lab., NIBRT, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland

Abstract

One hundred years have passed since Archibald Garrod postulated the one gene/one enzyme hypothesis. Since then, science has made significant progress and geneticists are now tackling an overwhelming complexity of gene regulation networks that underlie the genetics of complex human diseases. A particularly complex element in the biology of higher organisms is the genetics of proteinglycosylation. Nearly all proteins that appeared after the emergence of multicellular life are glycosylated, but instead of being molded by a single gene, glycan structures are encoded within a network of several hundred glycosyltransferases, glycosidases, transporters, transcription factors and other proteins. In addition, in contrast to the linear structures of DNA and proteins, glycans have multiple branches that make their analysis significantly more challenging. However, recent developments in high throughput HPLC analysis have advanced glycan analysis significantly and it is now possible to address questions about the complex genetics of proteinglycosylation. In this review we present some preliminary insights into this fascinating field.

Graphical abstract: Complex genetic regulation of proteinglycosylation

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Article information

DOI
https://doi.org/10.1039/B910377E
Article type
Review Article
Submitted
29 May 2009
Accepted
21 Sep 2009
First published
19 Oct 2009

Mol. BioSyst., 2010,6, 329-335

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Complex genetic regulation of proteinglycosylation

G. Lauc, I. Rudan, H. Campbell and P. M. Rudd, Mol. BioSyst., 2010, 6, 329 DOI: 10.1039/B910377E

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