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Positive association of CYP11B2 gene polymorphism with genetic predisposition to essential hypertension

Journal of Human Hypertension volume 16, pages 789–793 (2002)Cite this article

Abstract

Predispositions to essential hypertension and cardiovascular diseases are possibly associated with gene polymorphisms of the renin–angiotensin system. Gene polymorphisms of angiotensinogen and angiotensin-converting enzyme genes have been suggested to be risk factors for hypertension and myocardial infarction. Concerning the polymorphism of aldosterone synthase (CYP11B2) gene, earlier studies have shown inconsistent results in terms of its relation to hypertension. In the present case–control study, we investigated the association of −344T/C polymorphism in the promoter region of human CYP11B2 gene with genetic predisposition to hypertension. The genotype of −344T/C polymorphism was determined in essential hypertension subjects (n=250) and normotensive subjects (n=221). The distributions of three genotypes (TT, TC, and CC) were significantly different between the hypertensive and the normotensive groups (χ2=9.61, P=0.008). Namely, the frequency of C allele was higher in the hypertensive patients than in the normotensive subjects (34.2 vs 26.5%, P=0.010). Our data suggest that the −344C allele of CYP11B2 gene polymorphism is associated with the genetic predisposition to develop essential hypertension.

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Acknowledgements

We thank Ms Yasuko Kawamura, Ms Mika Nomura, Ms Jun Chou, Ms. Masako Minato, Ms Machiko Sakata and Ms Yasuko Mamada for technological assistance in executing the study. This study was supported in part by a grant-in-aid for scientific research (10218209) from the Ministry of Education, Science and Culture of Japan.

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Authors and Affiliations

  1. Department of Hypertension and Cardiorenal Medicine, Mibu, Tochigi, Japan

    K Tsukada, T Ishimitsu, M Teranishi, M Saitoh, M Yoshii, H Inada, S Ohta, M Akashi, J Minami, H Ono & H Matsuoka

  2. Department of Health Care, Dokkyo University School of Medicine, Mibu, Tochigi, Japan

    M Ohrui

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  1. K Tsukada
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  2. T Ishimitsu
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Correspondence to T Ishimitsu.

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Tsukada, K., Ishimitsu, T., Teranishi, M. et al. Positive association of CYP11B2 gene polymorphism with genetic predisposition to essential hypertension. J Hum Hypertens 16, 789–793 (2002). https://doi.org/10.1038/sj.jhh.1001484

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