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Association of left ventricular diastolic dysfunction with 24-h aortic ambulatory blood pressure: the SAFAR study

Journal of Human Hypertension volume 29, pages 442–448 (2015)Cite this article

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Abstract

Aortic blood pressure (BP) and 24-h ambulatory BP are both better associated with target organ damage than office brachial BP. However, it remains unclear whether a combination of these two techniques would be the optimal methodology to evaluate patients’ BP in terms of left ventricular diastolic dysfunction (LVDD) prevention. In 230 participants, office brachial and aortic BPs were measured by a validated BP monitor and a tonometry-based device, respectively. 24-h ambulatory brachial and aortic BPs were measured by a validated ambulatory BP monitor (Mobil-O-Graph, Germany). Systematic assessment of patients’ LVDD was performed. After adjustment for age, gender, hypertension and antihypertensive treatment, septum and lateral E/Ea were significantly associated with office aortic systolic BP (SBP) and pulse pressure (PP) and 24-h brachial and aortic SBP and PP (P⩽0.04), but not with office brachial BP (P⩾0.09). Similarly, 1 standard deviation in SBP was significantly associated with 97.8±20.9, 86.4±22.9, 74.1±23.3 and 51.3±22.6 in septum E/Ea and 68.6±20.1, 54.2±21.9, 37.9±22.4 and 23.1±21.4 in lateral E/Ea, for office and 24-h aortic and brachial SBP, respectively. In qualitative analysis, except for office brachial BP, office aortic and 24-h brachial and aortic BPs were all significantly associated with LVDD (P⩽0.03), with the highest odds ratio in 24-h aortic SBP. Furthermore, aortic BP, no matter in the office or 24-h ambulatory setting, showed the largest area under receiver operating characteristic curves (P⩽0.02). In conclusion, 24-h aortic BP is superior to other BPs in the association with LVDD.

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Acknowledgements

We thank all the investigators and patients who participated in this study.

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Authors and Affiliations

  1. Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China

    Y Zhang

  2. 1st Department of Propaedeutic Medicine, Hypertension Center and Cardiovascular Research Laboratory, Laiko Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece

    G Kollias, A A Argyris, C Tountas, G D Konstantonis, P P Sfikakis & A D Protogerou

  3. 1st Department of Cardiology, Biomedical Engineering Unit, Hippokration Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece

    T G Papaioannou

  4. 3rd University Department of Medicine, Hypertension Center, Sotiria Hospital, Athens, Greece

    A Achimastos

  5. Paris Descartes University; AP-HP; Diagnosis and Therapeutic Center, Hôtel-Dieu,

    J Blacher & M E Safar

  6. AP-HP, Paris, France

    J Blacher & M E Safar

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  1. Y Zhang
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  9. M E Safar
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Correspondence to A D Protogerou.

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Zhang, Y., Kollias, G., Argyris, A. et al. Association of left ventricular diastolic dysfunction with 24-h aortic ambulatory blood pressure: the SAFAR study. J Hum Hypertens 29, 442–448 (2015). https://doi.org/10.1038/jhh.2014.101

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  • DOI: https://doi.org/10.1038/jhh.2014.101

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