Original articleThe Prevalence of Retinal Vein Occlusion: Pooled Data from Population Studies from the United States, Europe, Asia, and Australia
Section snippets
Study Selection and Inclusion
A systematic review of the literature for all relevant population-based studies that undertook retinal photography was conducted. We searched all English language and human subject articles using a keyword search of MEDLINE (1950 to November 13, 2008), EMBASE (<1966 to December 18, 2008), Current Contents (1999 to December 18, 2008), and the Cochrane Library (to December 18, 2008) using the following search terms: retinal photography OR retinal images OR fundus photography AND population based.
Results
Overall, we collated data for 68,751 participants from 15 studies from the United States, Europe, Asia, and Australia. Of these participants, 43.7% were male, 48.4% were white, 27.1% were Asian, 17.2% were Hispanic, and 7.2% were black. Summary characteristics of each of the included studies are presented in Table 1; detailed characteristics of the participants in each of these studies have been described in previous publications (Table 1).
The majority of studies were conducted in only 1 ethnic
Discussion
The pooling of individual-level data from studies from the United States, Europe, Asia, and Australia allowed us to estimate more precisely the prevalence of RVO in the general adult population. On the basis of approximately 50,000 people from 11 studies that had assessed RVO from fundus photographs of 2 or more fields taken from each of the 2 eyes per participant, we estimate an age- and sex-standardized prevalence of 4.42 per 1000 persons for BRVO and 0.80 per 1000 persons for CRVO. The
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Cited by (0)
Manuscript no. 2009-189.
Financial Disclosure(s): The author(s) have made the following disclosure(s):
Authors Kowalski and Nguyen are both employees of Allergan Inc., which provided funding for this project.
Funding for the data pooling analysis was provided by Global Health Outcomes Research, Allergan, Inc, Irvine, California.
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Group members of the International Eye Disease Consortium are listed in Appendix 1, available at http://aaojournal.org.