Original articleEfficacy of periodontal treatment on glycaemic control in diabetic patients: A meta-analysis of interventional studies
Section snippets
Abbreviations
- HbA1c
glycated haemoglobin
- QUOROM
quality of reporting of meta-analyses
Material and methods
The QUOROM guidelines for meta-analyses of interventional studies were followed at all stages of the meta-analytical process [12].
Trial flow
From the 978 studies initially selected by their titles, we identified 25 interventional studies [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41]. Among these 25, 16 were non-controlled trials and nine were controlled trials. The meta-analysis was performed using the nine controlled studies obtained from seven articles [34], [35], [36], [37], [38], [39], [40], [41] (one article [34] reported on two
Discussion
This extensive literature review shows that the control of periodontal disease could be an important part of the overall management of diabetic patients. Indeed, our meta-analysis of nine controlled studies may lead some to conclude that periodontal therapy may improve glycaemic control. Interpretation of an SMD is less straightforward than interpretation of the original measures of difference between HbA1c levels. To address this problem, back-transforming the SMD (in this case, 0.46) is
Conflict of interest
None to declare.
Acknowledgements
The authors wish to thank: Marie-Cécile Valéra for her assistance with the bibliography searches; Samer Nuwwareh and Alessandra Blaizot for their constructive comments on quality assessment; Wei Yan-Vergnes for assistance with the translation of the Chinese papers; Omid and Manouchehr Naghizadeh for the Persian paper; Susan Becker for her advice on preparing the manuscript; and all of the authors who provided their additional data.
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