Original articleAdult cardiacPrognosis of Patients on Extracorporeal Membrane Oxygenation: The Impact of Acute Kidney Injury on Mortality
Section snippets
Patient Information and Data Collection
The local Institutional Review Board approved the study protocol (96-0004B). The medical records of 102 of 120 patients on ECMO support in a 20-bed specialized cardiovascular surgery intensive care unit between March 2002 and January 2008 were examined. Patients on ECMO support who did within 48 hours (18 patients) were excluded.
Retrospective data obtained are as follows: demographics; primary diagnosis for ECMO implementation; AKIN scores at pre-ECMO support (AKIN0-hour); at post-ECMO 24 hours
Subject Characteristics
The study population comprised 102 patients on ECMO support at the cardiovascular surgery intensive care unit between March 2002 and January 2008. Patient median age was 52 years; 62 (61%) were male and 40 (39%) were female. In-hospital mortality for the entire group was 57.8% (59 of 102). Table 2 lists patient demographic data and clinical characteristics for both survivors and nonsurvivors. An extremely high mortality rate, 85% (22 of 26) was noted for patients treated with ECMO and CRRT, 83%
Comment
Several previous studies have identified a mortality rate of 48% to 76% for patients on ECMO support [1, 2, 11, 12]. The hospital mortality rate for patients in this study was 57.8%. Analytical results confirm this grave prognosis for this patient subgroup on ECMO support. The AKIN group attempted to improve the sensitivity and reproducibility of AKI criteria and defined the AKIN classification. We propose that AKIN48-hour score can increase the accuracy of short-term prognosis in this patient
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