Original article: cardiovascularNeurocognitive deficit following coronary artery bypass grafting: a prospective study of surgical patients and nonsurgical controls
Section snippets
Patients
After approval was obtained by the Ethics Committee of the University of Vienna, 105 patients who underwent elective coronary artery bypass grafting at our department between January and December 1999, gave their written informed consent and were enrolled in this prospective study. Exclusion criteria were a history of one of the following medical conditions [1]: prior stroke with residual deficit [2], uncontrolled hypertension [4], carotid artery stenosis 75% [4], psychiatric illness requiring
Results
One hundred four patients undergoing isolated coronary artery bypass grafting at our institution were prospectively followed. The baseline characteristics of patients as well as controls are given in Table 1.
Comment
When compared with nonsurgical controls, coronary artery bypass grafting truly causes long-term neurocognitive deficit. Predictive variables for long-term neurocognitive deficit are neurocognitive deficit at 4-month follow-up, age, and persistent atrial fibrillation.
Neurocognitive deficit, defined as a combination of deficits in memory, learning, concentration and visual motor response, is an adverse event of coronary artery bypass grafting with an incidence of up to 80% perhaps the most common
Acknowledgements
We thank Daniela Dunkler, MS(Stat), for the statistical analysis of the work.
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