Effect of increasing metabolic syndrome score on atherosclerotic risk profile and coronary artery disease angiographic severity
Section snippets
Methods
We collected clinical, biochemical, and angiographic information in 1,108 consecutive patients (793 men and 315 women; age 58.1 ± 9.8 years) who underwent elective coronary angiography between April 1991 and March 1992. Most patients were white and of French-Canadian origin. All patients signed an informed consent form permitting the anonymous use of their data for research purposes, and the study was approved by our Internal Ethics Review Board.
Our database contained information about all the
Relative frequency of patients with 0 to 5 markers of the MS and relative frequency of various markers
The distribution of patients with a 0 to 5 MS score is listed in Table 1. In most groups, a low HDL cholesterol was the most frequent abnormality, followed by high normal or elevated blood pressure and increased triglycerides, waist circumference, and glucose levels.
Demographic and clinical characteristics of patients with the MS
Results are listed in TABLE 2, TABLE 3. As the number of constituents of the MS rose, so did age and blood pressure. Particularly striking was the progressive increase in the indexes of body weight and abdominal obesity (Table 2).
Discussion
As previously emphasized3 and as shown in the present study, >50% of our patients with CAD fulfilled the diagnostic criteria of the MS as recently defined by NCEP ATP III.1 This high incidence underscores the clinical importance of this diagnosis. Most of our patients were of French-Canadian origin; patients from different ethnic groups, or those without CAD, may have a lower prevalence of MS. As stated earlier, the MS has been shown to affect at least 20% of the U.S. adult population, and its
Acknowledgements
We are grateful to: A.M. Poirier, RN, for her excellent contribution in the collection of baseline clinical data; C. Hudon, RT, F. Lair, RT, M. Pilon, RT, and the other biochemistry laboratory technicians for measuring the chemical parameters; and D. Campeau and F. Thériault for their secretarial help in the preparation of this manuscript.
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