General Obstetrics and Gynecology: ObstetricsWhat proportion of birth weight is attributable to maternal glucose among infants of diabetic women?
Section snippets
Material and methods
All patients were treated at Kaiser Foundation Hospital, Bellflower, Calif. Women requiring insulin treatment of their diabetes during pregnancy were eligible for inclusion in the study. Their memory-based meters were calibrated to whole blood glucose values and recorded the date and time of each glucose measurement (One Touch 2 and One Touch Profile, Lifescan, Johnson & Johnson, Milpitas, CA). Patients were requested to return for office visits every 1 to 2 weeks at which time their glucose
Results
The data of 198 diabetic women who had been treated from January 1, 1997, to December 31, 2002, were available for review. Of these, 97 (46 GDM, 44 type 2, and 7 type 1 diabetic women) met inclusion criteria. The data of the remaining 101 subjects were excluded because they had been treated for fewer than 12 weeks. Because of their small numbers, the data of the type 1 diabetic women were also excluded from analysis. For the women found to have GDM, the mean gestational age at glucose tolerance
Comment
The results of this study suggest that in pregnancies of women who have GDM and type 2 diabetes requiring insulin both maternal glucose in third trimester and maternal prepregnancy BMI are independent predictors of infants' birth weights. Together these 2 variables explained 18% of the variance in birth weight for gestational age and gender. There did not appear to be much variation in the strength of the relationship between maternal glucose and birth weight percentile at different times of
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Cited by (44)
Maternal Age and Pregnancy
2020, Encyclopedia of Infant and Early Childhood DevelopmentPredictors of Large-for-Gestational-Age Birthweight Among Pregnant Women With Type 1 and Type 2 Diabetes: A Retrospective Cohort Study
2019, Canadian Journal of DiabetesCitation Excerpt :Previous studies regarding the relationship between maternal glycemic control and LGA for women with T2DM are also conflicting. Although 1 study of 51 women with T2DM in Chile found that A1C was not predictive of LGA (13), another study of 90 women in the United States with either insulin-dependent gestational diabetes or T2DM found that self-monitored blood glucose measures in the third trimester were associated with birthweight (26). One possible explanation for why studies have failed to consistently show an association between A1C and LGA may be because A1C may not be the best measure of glycemic control.
Update on Gestational Diabetes
2010, Obstetrics and Gynecology Clinics of North AmericaThe role of genetics in fetal programming of adult cardiometabolic disease
2022, Journal of Developmental Origins of Health and Disease
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