Original articleNormative Data for Macular Thickness by High-Definition Spectral-Domain Optical Coherence Tomography (Spectralis)
Section snippets
Methods
Informed consent was obtained from all subjects before study procedures were carried out. Subjects who had a best-corrected visual acuity (BCVA) of 20/20 or better in at least 1 eye with no history or clinical evidence of retinal disease were included in the study. Initial evaluation included BCVA testing, applanation tonometry, slit-lamp biomicroscopy, and fundus evaluation. OCT testing was performed by an experienced operator using Spectralis SD-OCT. All testing was carried out by the same
Results
Fifty normal eyes from 50 healthy subjects were examined clinically and underwent Spectralis SD-OCT testing and measurement. The ages ranged from 20 to 84 years (median, 43 years) and were divided into 3 age groups: group 1 consisted of subjects ranging from 20 to 40 years of age (n = 19), group 2 consisted of subjects ranging from 41 to 60 years of age (n = 20), and group 3 consisted of subjects 61 years of age and older (n = 11). There were 24 women (48%) and 26 men (52%) included in the
Discussion
In the past few years, OCT has emerged as a useful and adjunctive imaging technique, providing high-resolution cross-sectional images and valuable information about various pathologic features of the macula.1, 2 Quantification of macular thickness by OCT in a reproducible, noninvasive way allows clinicians to monitor the efficacy of treatment for macular pathologic features like diabetic macular edema.13, 14 The SD-OCT increases the speed of data collection by a factor of 100 (conventional
References (19)
- et al.
Imaging of macular diseases with optical coherence tomography
Ophthalmology
(1995) - et al.
Three-dimensional retinal imaging with high-speed ultra-high resolution optical coherence tomography
Ophthalmology
(2005) - et al.
Clinical application of rapid serial Fourier-domain optical coherence tomography for macular imaging
Ophthalmology
(2006) - et al.
Optical coherence tomography
Science
(1991) - et al.
Quantitative assessment of macular edema with optical coherence tomography
Arch Ophthalmol
(1995) - et al.
Optical coherence tomography for retinal thickness measurement in diabetic patients without clinically significant macular edema
Ophthalmic Surg Lasers
(2000) - et al.
Retinal thickness study with optical coherence tomography in patients with diabetes
Invest Ophthalmol Vis Sci
(2002) - et al.
High-definition and 3-dimensional imaging of macular pathologies with high-speed ultra-high resolution optical coherence tomography
Ophthalmology
(2006) - et al.
Normal macular thickness measurements in healthy eyes using Stratus optical coherence tomography
Arch Ophthalmol
(2006)