Original articleReproducibility of Retinal Thickness Measurements in Healthy Subjects Using Spectralis Optical Coherence Tomography
Section snippets
Methods
Forty-one eyes of 41 healthy subjects (mean age, 28 ± 5 years; 24 females) were included into the study. Exclusion criteria were the presence of a refractive error of > ±5 diopters (D), astigmatism of > 2 D, media opacifications, a history of ocular trauma or ocular diseases affecting the cornea, lens, retina, or optic nerve. The intraocular pressure (IOP) of the study eye had to be between 11 mm Hg and 21 mm Hg. All subjects received a slit-lamp exam, fundus biomicroscopy, and indirect
Results
The Table shows mean retinal thickness values, SDs, and COV values for the nine ETDRS areas tested. Retinal thickness measurements were highly reproducible for all ETDRS areas. Mean total retinal thickness was 342 ± 15 μm. Mean foveal thickness was 286 ± 17 μm. Mean difference between measurement 1 and 2, measurement 1 and 3, and measurement 2 and 3 for all ETDRS areas was 1.01 μm, 0.98 μm, and 0.99 μm, respectively. Mean COV was 0.54 ± 0.13%. Lowest COV was found for the temporal outer ETDRS
Discussion
The latest commercially available generation of FD-OCT has several advantages compared with conventional TD-OCT. High-speed imaging allows increasing the number of acquired B scans to yield greater retinal coverage and high-definition 3-dimensional images. Higher scan density leads to more detailed retinal thickness maps with less need of data interpolation. In this study, 37 B scans were used to scan a 20 × 15 degree area centered on the fovea. The Spectralis OCT has the option to increase
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