Elsevier

Neurotoxicology and Teratology

Volume 19, Issue 2, March–April 1997, Pages 129-140
Neurotoxicology and Teratology

Article
Toluene-induced hearing loss: A mid-frequency location of the cochlear lesions

https://doi.org/10.1016/S0892-0362(96)00214-0Get rights and content

Abstract

Inhaled toluene (from 1000 to 2000 ppm, 6 h/day, 5 days/week, 4 weeks) is an ototoxic solvent that severely damaged the cochlea in adult Long-Evans rats. Auditory function was tested by recording near field potentials from the inferior colliculus. Surprisingly, the electrophysiologic results did not reflect all the cochlear damage observed by histology. Loss of outer hair cells of the organ of Corti occurred in all toluene-treated rats in middle and mid-apical turns, whereas the basal turn of the cochlea was fairly well preserved. The third row of outer hair cells was more injured than the second row, which itself was more injured than the first row. The locations of the cochlear lesions are reported in the present study with regard to the toluene dose.

References (46)

  • C. Abbate et al.

    Neurotoxicity induced by exposure to toluene

    Int. Arch. Occup. Environ. Health

    (1993)
  • R. Altschuler et al.

    Acoustic stimulation and overstimulation in the cochlea: A comparison between basal and apical turns of the cochlea

  • B. Bergström et al.

    Development of hearing loss during long-term exposure to occupational noise

    Scand. Audiol.

    (1986)
  • B.A. Bohne

    Location of small cochlear lesions by phase contrast microscopy prior to thin sectioning

    Laryngoscope

    (1972)
  • H. Burda et al.

    Cochlea in old world mice and rats (Muridae)

    J. Morphol.

    (1988)
  • D. Deschamps et al.

    Evoked potentials and cerebral blood flow in solvent induced psycho-organic syndrome

    Br. J. Ind. Med.

    (1993)
  • A. Forge et al.

    Freeze fracture analysis of apical membranes in cochlear cultures: Differences between basal and apicalcoil outer hair cells and effects of neomycin

    J. Neurocytol.

    (1993)
  • R. Harrison et al.

    AP tuning curves from normal and pathologic human and guinea pig cochlea

    J. Acoust. Soc. Am.

    (1981)
  • D. Henderson et al.

    Evoked-response audibility curve of the chinchilla

    J. Acoust. Soc. Am.

    (1973)
  • J.T. Hormes et al.

    Neurologic sequelae of chronic solvent vapor abuse

    Neurology

    (1986)
  • A. Johnson et al.

    Progressive hair cell loss induced by toluene exposure

    Scand. Audiol. Suppl.

    (1993)
  • R. Kirk-Othmer

    Encyclopedia of chemical technology

    Economic Aspects

    (1983)
  • R. Lataye et al.

    Applicability of the Leq as a damage-risk criterion. An animal experiment

    J. Acoust. Soc. Am.

    (1996)
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