Age-related changes in intraocular pressure in a large japanese population: A cross-sectional and longitudinal study1
Section snippets
Methods
The subjects were 72,081 Japanese (45,000 men and 27,081 women) 20 to 79 years of age who had received annual examinations at health centers in Nagoya between 1989 and 1997. These examinations included visual acuity, tonometry, an interview, anthropometric measurements, blood pressure, and blood chemistry on the same day. Most of the subjects were office workers and their families residing in Aichi Prefecture in the central region of Japan. The 2438 subjects (1779 men and 659 women) who were
Cross-sectional analysis
Mean values of IOP, systolic blood pressure, diastolic blood pressure, and BMI were shown by age group and gender (Table 1). Age, IOP, blood pressure, and BMI were significantly higher in men than in women for all subjects (Student’s t test; P < 0.001). Systolic blood pressure and diastolic blood pressure increased with age, especially in women. Figure 1 shows a 3-year moving average of IOP in men and women. In subjects younger than 60 years, men had higher IOP than did women (Student’s t test;
Discussion
Positive correlation between age and IOP has been reported in many cross-sectional studies in America and Europe.7, 8, 9, 10, 11, 12, 13 It also was found that IOP was more strongly correlated with systolic blood pressure than with age.7, 14, 18, 21 In Japan, Shiose16 and Shiose and Kawase17 indicated a negative correlation for IOP with age and a positive correlation with body weight and blood pressure. Conversely, there are few longitudinal studies on the influences of age and blood pressure
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The authors have no financial interests related to the article.