Research LettersBrain natriuretic peptide and left ventricular dysfunction in Chagas' disease
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Cited by (63)
Vagal dysautonomia in patients with Chagas disease and mortality: 14-year results of a population cohort of the elderly
2024, Journal of ElectrocardiologyState-of-the-art in host-derived biomarkers of Chagas disease prognosis and early evaluation of anti-Trypanosoma cruzi treatment response
2020, Biochimica et Biophysica Acta - Molecular Basis of DiseaseCitation Excerpt :Both peptides are strong predictors of mortality, and are some of the most well characterized markers for assessing early cardiac damage and predicting heart failure outcome. Measurement of BNP levels has also been suggested for the prognosis of patients presenting left ventricular systolic dysfunction, one of the typical signs of cardiac Chagas disease [22,25–27]. The use of natriuretic peptides in the context of Chagas disease has also been studied in combination with other host-derived molecules.
Value of the Electrocardiographic (P Wave, T Wave, QRS) Axis as a Predictor of Mortality in 14 Years in a Population With a High Prevalence of Chagas Disease from the Bambuí Cohort Study of Aging
2018, American Journal of CardiologyCitation Excerpt :Also, some variables with known prognostic implications were not systematically collected: left ventricular ejection fraction —strongly associated with cardiovascular mortality—was not available for inclusion in the multivariable mortality models. We believe, however, that the results remain valid, once we used the BNP levels—with marked inverse correlation with left ventricular ejection fraction and mortality in cardiomyopathies28,29—as a reliable surrogate for left ventricular function. Finally, only baseline data were available for most variables, including ECG and laboratory results.
Chronic Chagas Heart Disease Management: From Etiology to Cardiomyopathy Treatment
2017, Journal of the American College of CardiologyChagas Disease Diagnostic Applications: Present Knowledge and Future Steps
2017, Advances in ParasitologyCitation Excerpt :Alternatively, several groups attempted to identify biochemical markers of cardiac damage and/or inflammation such as TNF-α (Talvani et al., 2004a), angiotensin-converting enzyme 2 (ACE2) (Wang et al., 2010), brain and atrial natriuretic peptides (BNP and ANP, respectively) (Garcia-Alvarez et al., 2010; Heringer-Walther et al., 2005; Ribeiro et al., 2002) as candidates for disease prognosis (Table 1). In particular, the concentrations of BNP and ANP in serum were systematically studied as markers of heart damage in Chagasic patients (Garcia-Alvarez et al., 2010; Heringer-Walther et al., 2005; Ribeiro et al., 2002) since they had been previously related with cardiovascular diseases (Wang et al., 2006; Wondergem et al., 2001). Increased concentrations of BNP and ANP strongly correlated with the severity of Chagas-associated cardiac damage, being BNP more sensitive than ANP (Fernandes et al., 2007; Heringer-Walther et al., 2005; Talvani et al., 2004b).
Inflammatory and cardiac biomarkers are differentially expressed in clinical stages of Chagas disease
2015, International Journal of Cardiology