Asymmetric otolith vestibulo-ocular responses in children with idiopathic scoliosis☆,☆☆,★,★★
Section snippets
Study Design
Three groups of children were studied: a group of 30 patients with IS, a control group of 12 children with normal posture and free from pathologic condition, and a third group of 3 children with a scoliosis caused by congenital vertebral deformities, such as hemivertebrae (data available from authors). All children had orthopedic, neurologic, and otorhinolaryngologic clinical examinations to exclude other possibly relevant pathologic conditions. In addition, all underwent pure-tone audiometry
Results
In 20 of the 30 patients with IS, the mean absolute values of otolith DP were greater than those of the entire group of control subjects (Fig. 3).
Discussion
In this database, 66.7% of the patients with IS have otolith responses with greater asymmetry than matched control subjects. One possible explanation is that a peripheral dysfunction of the otolith receptors is a major factor in the cause of these cases of IS. A study in adult guinea pigs showed that selective experimental lesions of the otolith receptors induce deformations of the spine comparable in many ways to those observed in children with IS.7 Selective lesions of the otolith receptors
Acknowledgements
We thank Prof. Philippe Narcy (Chief of the Otorhinolaryngology Department at Robert Debré Hospital) and Prof. Georges-François Penneçot (Chief of the Department of Orthopedic Surgery at Robert Debré Hospital) for their contribution to the study. We also thank Dr. Sidney Wiener and Prof. Pierre Denise who provided helpful comments on the text.
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Cited by (70)
Sensorimotor Control Impairment in Young Adults With Idiopathic Scoliosis Compared With Healthy Controls
2016, Journal of Manipulative and Physiological TherapeuticsDoes adolescent idiopathic scoliosis relate to vestibular disorders? A systematic review
2014, Annals of Physical and Rehabilitation MedicineCitation Excerpt :Il est donc difficile d’en tirer des conclusions générales. Les 2 seules études par stimulation du système otolithique sont en faveur de perturbations dans la SIA, par rapport aux populations témoins [17,26]. Ces résultats sont renforcés par l’existence d’anomalies IRM au niveau du sillon latéral (ou scissure de Sylvius), siège probable d’intégration des informations otolithiques [11,34].
Development of the Central Vestibular System
2014, Development of Auditory and Vestibular Systems: Fourth EditionIs abnormal vestibulomotor responses related to idiopathic scoliosis onset or severity?
2013, Medical HypothesesCitation Excerpt :Because the lateral vestibulospinal tract controls axial muscles, alteration in the brainstem during body growth (i.e., preadolescent and adolescent period) may translate in abnormal trunk activation and cause permanent spine deformities. Consequently, during the last decades, several authors have suggested that scoliosis onset may be related to impairment of the vestibular system because of its contribution to regulation of axial muscles tone e.g. [5,11–13]. Nonetheless, no study has addressed whether direct vestibular stimulation would lead to abnormal motor response in patients with AIS compared to controls.
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From the Otorhinolaryngology Department and the Department of Orthopedic Surgery, Hôpital Robert Debré, Paris, France.
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Supported by the CNES, INSERM, Fondation pour la Recherche Médicale, Fondation de France, and The Reuter Fondation.
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Reprint requests: Sylvette R. Wiener-Vacher, MD, Hôpital Robert Debré, Département d'ORL, 48 bld Sérurier, 75019 Paris, France.
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