Journal of the American Dietetic Association
The DASH Diet, Sodium Intake and Blood Pressure Trial (DASH-Sodium): Rationale and Design
Section snippets
Research Questions and Rationale
The DASH Diet, Sodium Intake and Blood Pressure Trial (DASH-Sodium) is an ongoing multicenter, randomized controlled feeding trial designed to evaluate the separate and combined effects of sodium reduction and the DASH diet in reducing blood pressure among adults with higher than optimal blood pressure or with stage 1 hypertension (120 to 159/80 to 95 mm Hg). The study began in February 1997 and will be completed by February 2001. The sodium levels to be tested include higher intake, consistent
Methods
DASH-Sodium is an investigator-initiated multicenter clinical trial supported by the National Heart, Lung, and Blood Institute (NHLBI). Collaborating on this trial are scientists from 4 clinical centers, a coordinating center, a central food analysis laboratory, a central blood and urine analysis laboratory, and NHLBI. After eligibility screening, all participants enter a 2-week run-in feeding period during which they eat the control dietary pattern at the higher sodium level. They are then
Discussion
The DASH-Sodium study will determine the independent blood pressure–lowering effects of sodium reduction and of the DASH diet (which emphasizes fruits, vegetables, and low-fat dairy products, includes whole grains, poultry, fish, and nuts, and is reduced in fats, red meat, sweets, and sugar-containing beverages) in persons with higher than optimal blood pressure or stage 1 hypertension. Specifically, DASH-Sodium will determine the effect of sodium intake at 3 clinically relevant levels in the
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