Original articleDanazol and stanozolol in long-term prophylactic treatment of hereditary angioedema
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The international WAO/EAACI guideline for the management of hereditary angioedema – The 2021 revision and update
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2022, Allergic and Immunologic Diseases: A Practical Guide to the Evaluation, Diagnosis and Management of Allergic and Immunologic DiseasesThe international WAO/EAACI guideline for the management of hereditary angioedema - The 2017 revision and update
2018, World Allergy Organization JournalCritical appraisal of androgen use in hereditary angioedema: A systematic review
2015, Annals of Allergy, Asthma and ImmunologyCitation Excerpt :The long-term prophylactic effectiveness of androgen therapy for HAE has been evaluated in multiple prospective, open-label studies (LOE II).14–26 Danazol reduced the severity and frequency of HAE attacks15,16,19,20,26 and resulted in improvement of clinical symptoms.18,25 In some studies, nearly all patients were able to find an effective dose of danazol that completely prevented HAE attacks.16,19,20
WAO guideline for the management of hereditary angioedema
2012, World Allergy Organization JournalCitation Excerpt :In addition to clinical tests and examinations and questioning of the patient, semiannual blood and urine tests are needed, and at least once a year, an ultrasound of the liver should be performed. The goal of prophylaxis with androgens is the reduction of the severity and frequency of swelling events as far as possible with a reasonable dosing scheme [102–110]. Before the initiation of long-term prophylaxis with androgens, measurements of complete blood count, urine analysis, liver function tests, lipid profile, assessment of cardiac risk factors, and liver ultrasound should be performed.
Hereditary Angioedema Caused by C1-Esterase Inhibitor Deficiency: A Literature-Based Analysis and Clinical Commentary on Prophylaxis Treatment Strategies
2011, World Allergy Organization Journal