Glycolytic enzymes as DNA binding proteins
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Cited by (101)
Proteomic analysis in kidneys of Atlantic salmon infected with Aeromonas salmonicida by iTRAQ
2017, Developmental and Comparative ImmunologyGlyceraldehyde-3-phosphate dehydrogenase (GAPDH) interacts with apurinic/apyrimidinic sites in DNA
2015, Mutation Research - Fundamental and Molecular Mechanisms of MutagenesisEnzymes of the central carbon metabolism: Are they linkers between transcription, DNA replication, and carcinogenesis?
2015, Medical HypothesesCitation Excerpt :In some cases, the enzymes found in the nuclei represented the modified forms of those found in the cytoplasm. Interestingly, the nuclear forms of these enzymes were found to bind DNA (for discussion, see Ref. [18]). Since: (i) carcinogenesis depends on disruption of DNA replication regulation, (ii) there is an interplay between transcription and DNA replication processes, including the important role of promoters’ activities in the control of replication initiation, (iii) direct genetic links between central carbon metabolism and DNA replication regulation have been demonstrated recently, and (iv) some experimental results suggest that different enzymes involved in central carbon metabolism may contribute to regulation of transcription and DNA transactions (replication and repair), we propose the hypothesis that these proteins could be linkers between central carbon metabolism, transcription, and DNA replication.