Glycolytic enzymes as DNA binding proteins

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Abstract

  • 1.

    1. Numerous studies have demonstrated the presence of at least four glycolytic enzymes in the nuclear compartment of several cell systems.

  • 2.

    2. These include, lactate dehydrogenase, phosphoglycerate kinase, aldolase and glyceraldehyde-3-phosphate dehydrogenase.

  • 3.

    3. In some cases the glycolytic enzymes found in the nuclei were a modified form from that found in the cytoplasmic counterpart.

  • 4.

    4. In all four eases, the nuclear form of these glycolytic enzymes has been reported to bind DNA.

  • 5.

    5. Although none of these enzymes interact with a specific target DNA sequence, their association with DNA may play a role in transcription and replication of DNA through general stabilization of the nuclear matrix or chromatin structure.

  • 6.

    6. The present review aims to summarize the current understanding of this phenomenon and to examine the role of the DNA-binding activities of the glycolytic enzymes in cell growth and differentiation.

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    Citation Excerpt :

    In some cases, the enzymes found in the nuclei represented the modified forms of those found in the cytoplasm. Interestingly, the nuclear forms of these enzymes were found to bind DNA (for discussion, see Ref. [18]). Since: (i) carcinogenesis depends on disruption of DNA replication regulation, (ii) there is an interplay between transcription and DNA replication processes, including the important role of promoters’ activities in the control of replication initiation, (iii) direct genetic links between central carbon metabolism and DNA replication regulation have been demonstrated recently, and (iv) some experimental results suggest that different enzymes involved in central carbon metabolism may contribute to regulation of transcription and DNA transactions (replication and repair), we propose the hypothesis that these proteins could be linkers between central carbon metabolism, transcription, and DNA replication.

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