Skip to main content

Advertisement

SpringerLink
Log in

Association of plasma total and high-molecular-weight adiponectin with risk of colorectal cancer: an observational study in Chinese male

  • Original Paper
  • Published:
Medical Oncology Aims and scope Submit manuscript

Abstract

The research is to investigate the association between plasma concentrations of total and high-molecular-weight (HMW) adiponectin and risk of early and advanced colorectal cancer. One hundred and sixty-five male colorectal cancer patients and one hundred and two controls were enrolled; based on the T factor of the TNM system, intraepithelial carcinoma and submucosally invasive carcinoma were defined as early cancer, and invasion into the muscularis propria or deeper was defined as advanced cancer. The plasma levels of glucose, fasting insulin, total cholesterol, triglyceride, and total and HMW adiponectin levels were measured. Each factor level was designated as low or high, and the risk of cancer was estimated by univariate and multivariate logistic regression analyses. In the patients with early cancer, high waist/hip ratio (WHR), high fasting insulin, high HOMA model insulin resistance index (HOMA-IR), low total adiponectin and HMW adiponectin were all associated with a significant increase in the odds ratio (OR) by univariate analysis. In multivariate analysis, WHR, HOMA-IR, total adiponectin and HMW adiponectin were all related to increased cancer risk. However, in the patients with advanced cancer, only low HMW adiponectin was associated with a significant increase in the OR by univariate analysis. In multivariate analysis, a low HMW adiponectin level was still related to increased cancer risk, with an adjusted OR of 3.971 (P = 0.036). In conclusion, a decreased level of adiponectin was a strong risk factor not only for early colorectal cancer but also for advanced colorectal in Chinese male patients. HMW adiponectin might be more closely associated with colorectal cancer risk than total adiponectin.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Li M, Gu J. Changing patterns of colorectal cancer in China over a period of 20 years. World J Gastroenterol. 2005;11(30):4685–8.

    PubMed  Google Scholar 

  2. Calle EE, Kaaks R. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer. 2004;4(8):579–91.

    Article  PubMed  CAS  Google Scholar 

  3. Fasshauer M, Paschke R. Regulation of adipocytokines and insulin resistance. Diabetologia. 2003;46(12):1594–603.

    Article  PubMed  CAS  Google Scholar 

  4. Tschritter O, Fritsche A, Thamer C, Haap M, Shirkavand F, Rahe S, et al. Plasma adiponectin concentrations predict insulin sensitivity of both glucose and lipid metabolism. Diabetes. 2003;52(2):239–43.

    Article  PubMed  CAS  Google Scholar 

  5. Diez JJ, Iglesias P. The role of the novel adipocyte-derived hormone adiponectin in human disease. Eur J Endocrinol. 2003;148(3):293–300.

    Article  PubMed  CAS  Google Scholar 

  6. Barb D, Williams CJ, Neuwirth AK, Mantzoros CS. Adiponectin in relation to malignancies: a review of existing basic research and clinical evidence. Am J Clin Nutr. 2007;86(3):858–66.

    Google Scholar 

  7. Shetty GK, Economides PA, Horton ES, Mantzoros CS, Veves A. Circulating adiponectin and resistin levels in relation to metabolic factors, inflammatory markers, and vascular reactivity in diabetic patients and subjects at risk for diabetes. Diabetes Care. 2004;27(10):2450–7.

    Article  PubMed  CAS  Google Scholar 

  8. Engeli S, Feldpausch M, Gorzelniak K, Hartwig F, Heintze U, Janke J, et al. Association between adiponectin and mediators of inflammation in obese women. Diabetes. 2003;52(4):942–7.

    Article  PubMed  CAS  Google Scholar 

  9. Nishida M, Funahashi T, Shimomura I. Pathophysiological significance of adiponectin. Med Mol Morphol. 2007;40(2):55–67.

    Article  PubMed  CAS  Google Scholar 

  10. Ealey KN, Archer MC. Elevated circulating adiponectin and elevated insulin sensitivity in adiponectin transgenic mice are not associated with reduced susceptibility to colon carcinogenesis. Int J Cancer. 2009;124(9):2226–30.

    Article  PubMed  CAS  Google Scholar 

  11. Sugiyama M, Takahashi H, Hosono K, Endo H, Kato S, Yoneda K, et al. Adiponectin inhibits colorectal cancer cell growth through the AMPK/mTOR pathway. Int J Oncol. 2009;34(2):339–44.

    PubMed  CAS  Google Scholar 

  12. Kumor A, Daniel P, Pietruczuk M, MaA ecka-Panas E. Serum leptin, adiponectin, and resistin concentration in colorectal adenoma and carcinoma (CC) patients. Int J Colorectal Dis. 2009;24(3):275–81.

    Article  PubMed  Google Scholar 

  13. Erarslan E, Turkay C, Koktener A, Koca C, Uz B, Bavbek N. Association of visceral fat accumulation and adiponectin levels with colorectal neoplasia. Dig Dis Sci. 2009;54(4):862–8.

    Article  PubMed  CAS  Google Scholar 

  14. Wei EK, Giovannucci E, Fuchs CS, Willett WC, Mantzoros CS. Low plasma adiponectin levels and risk of colorectal cancer in men: a prospective study. J Natl Cancer Inst. 2005;97(22):1688–94.

    Article  PubMed  CAS  Google Scholar 

  15. Otake S, Takeda H, Fujishima S, Fukui T, Orii T, Sato T, et al. Decreased levels of plasma adiponectin associated with increased risk of colorectal cancer. World J Gastroenterol. 2010;16(10):1252–7.

    Article  PubMed  CAS  Google Scholar 

  16. Ma J, Giovannucci E, Pollak M, Leavitt A, Tao Y, Gaziano JM, et al. A prospective study of plasma C-peptide and colorectal cancer risk in men. J Natl Cancer Inst. 2004;96(7):546–53.

    Article  PubMed  CAS  Google Scholar 

  17. Wei EK, Ma J, Pollak MN, Rifai N, Fuchs CS, Hankinson SE, et al. A prospective study of plasma C-peptide, insulin-like growth factor-1, insulin-like growth factor binding protein-1 and the risk of colorectal cancer in women. Cancer Epidemiol Biomarkers Prev. 2005;14(4):850–5.

    Article  PubMed  CAS  Google Scholar 

  18. Schoen RE, Tangen CM, Kuller LH, Burke GL, Cushman M, Tracy RP, et al. Increased blood glucose and insulin, body size, and indent colorectal cancer. J Natl Cancer Inst. 1999;91(13):1147–54.

    Article  PubMed  CAS  Google Scholar 

  19. Xu XT, Xu Q, Tong JL, Zhu MM, Huang ML, Ran ZH, et al. Meta-analysis: circulating adiponectin levels and risk of colorectal cancer and adenoma. J Dig Dis. 2011;12(4):234–44.

    Article  PubMed  CAS  Google Scholar 

  20. An W, Bai Y, Deng SX, Gao J, Ben QW, Cai QC, et al. Adiponectin levels in patients with colorectal cancer and adenoma: a meta-analysis. Eur J Cancer Prev. 2012;21(2):126–33.

    Article  PubMed  CAS  Google Scholar 

  21. Lukanova A, Söderberg S, Kaaks R, Jellum E, Stattin P. Serum adiponectin is not associated with risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev. 2006;15(2):401–2.

    Article  PubMed  CAS  Google Scholar 

  22. Stocks T, Lukanova A, Johansson M, Rinaldi S, Palmqvist R, Hallmans G, et al. Components of the metabolic syndrome and colorectal cancer risk: a prospective study. Int J Obes (Lond). 2008;32(2):304–14.

    Article  CAS  Google Scholar 

  23. Yamaji T, Iwasaki M, Sasazuki S, Tsugane S. Interaction between adiponectin and leptin influences the risk of colorectal adenoma. Cancer Res. 2010;70(13):5430–7.

    Article  PubMed  CAS  Google Scholar 

  24. Fukumoto J, Otake T, Tajima O, Tabata S, Abe H, Mizoue T, et al. Adiponectin and colorectal adenoma: Self Defense Forces Health Study. Cancer Sci. 2008;99(4):781–6.

    Article  PubMed  CAS  Google Scholar 

  25. Aleksandrova K, Boeing H, Jenab M, Bueno-de-Mesquita HB, Jansen E, van Duijnhoven FJ, et al. Total and high-molecular weight and risk of colorectal cancer: the European Prospective Investigation into Cancer and Nutrition Study. Carcinogenesis. 2012;. doi:10.1093/carcin/bgs133.

    PubMed  Google Scholar 

  26. Bråkenhielm E, Veitonmäki N, Cao R, Kihara S, Matsuzawa Y, Zhivotovsky B, et al. Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis. Proc Natl Acad Sci USA. 2004;101(8):2476–81.

    Article  PubMed  Google Scholar 

  27. Sugiyama M, Takahashi H, Hosono K, Endo H, Kato S, Yoneda K, et al. Adiponectin inhibits colorectal cancer cell growth through the AMPK/mTOR pathway. Int J Oncol. 2009;34(2):339–44.

    PubMed  CAS  Google Scholar 

  28. Kim AY, Lee YS, Kim KH, Lee JH, Lee HK, Jang SH, et al. Adiponectin represses colon cancer cell proliferation via adipoR1-and-R2-mediated AMPK activation. Mol Endocrinol. 2010;24(7):1441–52.

    Article  PubMed  CAS  Google Scholar 

  29. Fujisawa T, Endo H, Tomimoto A, Sugiyama M, Takahashi H, Saito S, Inamori M, et al. Adiponectin suppresses colorectal carcinogenesis under the high-fat diet condition. Gut. 2008;57(11):1531–8.

    Article  PubMed  CAS  Google Scholar 

  30. Sandhu MS, Dunger DB, Giovannucci EL. Insulin, insulin-like growth factor-I(IGF-1), IGF binding proteins, their biologic interaction, and colorectal cancer. J Natl Cancer Inst. 2002;94(13):972–80.

    Article  PubMed  CAS  Google Scholar 

  31. Otani T, Iwasaki M, Sasazuki S, Inoue M, Tsugane S. Plasma C-peptide, insulin-like growth factor-I, insulin-like growth factor binding proteins and risk of colorectal cancer in a nested case-control study: the Japan public health center-based prospective study. Int J Cancer. 2007;120(9):2007–12.

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

We thank the participants of this study including the doctors, nurses, administrative staff and researchers from the Department of Endocrinology, Surgery, and Division of Endoscopy in The first affiliated Hospital of Anhui Medical University.

Conflict of interest

All authors have no any financial disclosures and conflicts of interest.

Author information

Authors and Affiliations

  1. Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, 210 JiXi Road, Hefei, 230032, People’s Republic of China

    Ming-Wei Chen, Shuai Ye, Li-Li Zhao & You-Min Wang

  2. Division of General surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, People’s Republic of China

    Shen-Yi Wang, Yong-Xiang Li & Chang-Jun Yu

  3. Division of Endoscopy, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, People’s Republic of China

    Hui-Juan Xie

Authors
  1. Ming-Wei Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Shuai Ye
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Li-Li Zhao
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Shen-Yi Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yong-Xiang Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Chang-Jun Yu
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Hui-Juan Xie
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. You-Min Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to You-Min Wang.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chen, MW., Ye, S., Zhao, LL. et al. Association of plasma total and high-molecular-weight adiponectin with risk of colorectal cancer: an observational study in Chinese male. Med Oncol 29, 3129–3135 (2012). https://doi.org/10.1007/s12032-012-0280-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12032-012-0280-2

Keywords

Search

Navigation