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Intragastric Balloon-Induced Satiety is Not Mediated by Modification in Fasting or Postprandial Plasma Ghrelin Levels in Morbid Obesity

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Background

The BioEnterics Intragastric Balloon (BIB) has been proposed as an adjuvant therapy for the short-term treatment of obesity. The temporal pattern of BIB-induced satiety and whether this effect is mediated by modification of ghrelin levels is unknown.

Methods

Patients with treatment-resistant morbid obesity were invited to participate in a randomized, double-blind, sham-controlled trial of 4-month duration. Anthropometric and biochemical parameters, estimation of energy intake, and pre- and postprandial evaluation of satiety were required monthly. Ghrelin response after a standard mixed meal was scheduled prior to and 4 weeks after the endoscopic procedure.

Results

21 out of 22 enrolled patients completed the study (17 women, 5 men; 35.9 ±–.9 years; BMI 50.4 ±–.8 kg/m2). Pre-intervention weight decreased from 143.8 ±–1.2 kg to 131.1 ±–2.6 kg in Group Balloon (P–lt;–.001) and from 138.8 ±–4.5 kg to 129.9 ±–5.6 kg in Group Sham (P–lt;–.01) at the end of the study. Weight loss was not significantly different in Group Balloon and Group Sham at any time-point of the follow-up. Only patients from Group Balloon showed a temporary increased pre- and postprandial satiety, which was maximal at 4 weeks after the intervention. Total area under the curve, fasting and postprandial plasma ghrelin were not significantly different between groups at inclusion or 4 weeks after follow-up. No correlation was found between any of the satiety scores at any time-point with their comparable ghrelin levels.

Conclusion

BIB induces a temporary sense of satiety in morbidly obese patients which is not mediated by modification of fasting or postprandial levels of plasma ghrelin.

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Authors and Affiliations

  1. Department of Endocrinology and Nutrition, University Hospital Virgen del Rocio, Seville, Spain

    Maria Asuncion Martinez-Brocca MD, Juana Parejo NP, Jose Luis Pereira MD, Ricardo Astorga MD, Alfonso Leal-Cerro MD & Pedro Pablo Garcia-Luna MD

  2. Department of Gastroenterology, University Hospital Virgen del Rocio, Seville, Spain

    Ovidio Belda MD

  3. Department of Clinical Biochemistry, University Hospital Virgen del Rocio, Seville, Spain

    Luis Jimenez PhD

  4. Section of Endocrine Surgery, Department of Surgery, University Hospital Virgen del Rocio, Seville, Spain

    Agustin del Valle MD

  5. Department of Nuclear Medicine, University Hospital Virgen del Rocio, Seville, Spain

    Felipe Garcia-Pesquera PhD

  6. Section of Clinical Nutrition. Department of Endocrinology and Nutrition, Hospital Universitario Virgen del Rocio, Avenida Manuel Siurot, s/n. 41013, Seville, Spain

    Pedro Pablo Garcia-Luna MD

Authors
  1. Maria Asuncion Martinez-Brocca MD
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  2. Ovidio Belda MD
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  3. Juana Parejo NP
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  4. Luis Jimenez PhD
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  5. Agustin del Valle MD
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  6. Jose Luis Pereira MD
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  7. Felipe Garcia-Pesquera PhD
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  8. Ricardo Astorga MD
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  9. Alfonso Leal-Cerro MD
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  10. Pedro Pablo Garcia-Luna MD
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Correspondence to Pedro Pablo Garcia-Luna MD.

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Martinez-Brocca, M.A., Belda, O., Parejo, J. et al. Intragastric Balloon-Induced Satiety is Not Mediated by Modification in Fasting or Postprandial Plasma Ghrelin Levels in Morbid Obesity. OBES SURG 17, 649–657 (2007). https://doi.org/10.1007/s11695-007-9109-z

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  • DOI: https://doi.org/10.1007/s11695-007-9109-z

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