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The PACIFIC (Prevention of AtherothrombotiC Incidents Following Ischemic Coronary attack) Registry: Rationale and Design of a 2-Year Study in Patients Initially Hospitalised with Acute Coronary Syndrome in Japan

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Abstract

Purpose

Atherothrombotic disease is a major and increasing health problem in Japan. Effective secondary prevention of atherothrombotic events after acute coronary syndrome (ACS) is required, but clinical evidence regarding the current state of preventive treatment and the rate of subsequent atherothrombotic events after ACS in Japan is limited. Up-to-date Japanese epidemiological real world data are required to construct optimal evidence-based Japanese guidelines for the management of patients with ACS.

Methods

The PACIFIC (Prevention of AtherothrombotiC Incidents Following Ischemic Coronary attack) Registry is an ongoing, observational study of a large cohort of Japanese patients hospitalised with any manifestation of ACS (ST-segment elevation myocardial infarction, non-ST-segment elevation myocardial infarction or unstable angina [UA]). Up to 4,000 patients from approximately 100 sites nationwide will be enrolled and the primary study endpoint is the incidence of any major atherothrombotic event (cardiovascular, cerebrovascular or peripheral) between the initial ACS event and 2 years of follow-up. Secondary endpoints include fatal myocardial infarction (MI), fatal stroke, other cardiovascular death, non-cardiovascular death, non-fatal MI/UA, non-fatal stroke and acute peripheral arterial occlusion. Hospitalisation for vascular interventions will also be recorded, as will haemorrhage requiring hospitalisation or blood transfusion. The use of preventive treatment will also be reported and different patient subgroups (diabetes mellitus, hypertension, dyslipidaemia and metabolic syndrome) will be analysed. It is expected that the study will be completed in early to mid 2011.

Conclusions

The PACIFIC Registry will give insights as to the Japanese epidemiology of ACS: recurrence of atherothrombotic events in the same or other vascular territories.

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Acknowledgments

This registry was supported by sanofi-aventis K.K. Editorial support was also provided by sanofi-aventis K.K.

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Authors and Affiliations

  1. Department of Cardiovascular Medicine, School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan

    Katsumi Miyauchi & Hiroyuki Daida

  2. Department of Cardiology, School of Medicine, Tokai University, Isehara, Japan

    Yoshihiro Morino

  3. Division of cardiology, Yokohama City University Medical Center, Yokohama, Japan

    Kengo Tsukahara

  4. Division of Biostatistics and Clinical Epidemiology, University of Toyama, Toyama, Japan

    Hideki Origasa

Authors
  1. Katsumi Miyauchi
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  2. Yoshihiro Morino
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  3. Kengo Tsukahara
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  4. Hideki Origasa
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  5. Hiroyuki Daida
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Consortia

on behalf of the PACIFIC steering committee members

Corresponding author

Correspondence to Hiroyuki Daida.

Appendix

Appendix

1.1 Steering committee

Hiroyuki Daida (Chief of steering committee), Department of Cardiovascular Medicine, School of Medicine, Juntendo University Tokyo, Japan; Hiroyuki Tsutsui, Department of Cardiovascular Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan; Takaaki Isshiki, Department of Internal Medicine, School of Medicine, Teikyo University, Tokyo, Japan; Yuji Ikari Department of Cardiology, School of Medicine, Tokai University, Isehara, Japan; Kazuo Kimura, Division of cardiology, Yokohama City University Medical Center, Yokohama, Japan; Tetsuo Matsubara, Department of Cardiology, Nagoya Heart Center, Nagoya, Japan; Takeshi Kimura, Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Masafumi Kitakaze, Cardiovascular Division of Medicine, National Cardiovascular Center, Suita, Japan; Masayasu Matsumoto, Departments of Clinical Neuroscience and Therapeutics, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima , Japan; Hisao Ogawa, Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; Hiroyoshi Yokoi, Department of Cardiology, Kokura Memorial Hospital, Kokura, Japan

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Miyauchi, K., Morino, Y., Tsukahara, K. et al. The PACIFIC (Prevention of AtherothrombotiC Incidents Following Ischemic Coronary attack) Registry: Rationale and Design of a 2-Year Study in Patients Initially Hospitalised with Acute Coronary Syndrome in Japan. Cardiovasc Drugs Ther 24, 77–83 (2010). https://doi.org/10.1007/s10557-010-6223-2

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  • DOI: https://doi.org/10.1007/s10557-010-6223-2

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