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Association between clinical diagnostic tests and health-related quality of life surveys in patients with dry eye syndrome

  • Clinical Investigation
  • Published:
Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

This study was performed to assess the impact of dry eye on patients’ quality of life (QOL) and to analyze the association between subjective symptoms and ocular surface findings of dry eye.

Methods

The study population consisted of 158 patients with dry eye aged 20 years or older who visited any of the 15 medical care facilities enrolled in the study. The backgrounds and ocular findings of the patients were investigated, and their QOL was evaluated with the Japanese version of the 25-item National Eye Institute Visual Functioning Questionnaire (VFQ-25) and of the Medical Outcomes Study (MOS) 8-item Short-Form Health Survey (SF-8) to examine the association between subjective symptoms and ocular surface findings.

Results

Of the patients enrolled, 15 were men and 143 were women, and their average age was 62.5 ± 12.6 years. Sixty patients (38.0%) had comorbid Sjögren syndrome (SS). The results of Schirmer testing, fluorescein staining, and rose bengal staining for SS patients were significantly worse than those for the non-SS patients, but the VFQ-25 and SF-8 scores were not significantly different between the SS and non-SS patients. In the ocular surface findings, a weak association between the fluorescein staining scores and general vision scores, a subscale of the VFQ-25, was found. However, the ocular surface findings and VFQ-25/SF-8 results in the simple correlation analysis as well as in the multiple linear regression analysis showed no significant associations.

Conclusions

Ocular surface findings and QOL scores of patients with dry eye appear to disagree. Therefore, it is necessary to address subjective symptoms and QOL scores in addition to examination findings when evaluating dry eye.

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Author information

Authors and Affiliations

  1. Division for Vision Research, National Institute of Sensory Organs, National Tokyo Medical Center, Tokyo, Japan

    Yoshinobu Mizuno, Masakazu Yamada & Yozo Miyake

  2. Department of Ophthalmology, Aichi Shukutoku University Clinic, Aichi, Japan

    Yozo Miyake

  3. Division for Vision Research, National Institute of Sensory Organs, National Tokyo Medical Center, 2-5-1 Higashigaoka, Meguro-ku, Tokyo, 152-8902, Japan

    Yoshinobu Mizuno

Authors
  1. Yoshinobu Mizuno
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  2. Masakazu Yamada
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  3. Yozo Miyake
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Consortia

Dry Eye Survey Group of the National Hospital Organization of Japan

Corresponding author

Correspondence to Yoshinobu Mizuno.

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Mizuno, Y., Yamada, M., Miyake, Y. et al. Association between clinical diagnostic tests and health-related quality of life surveys in patients with dry eye syndrome. Jpn J Ophthalmol 54, 259–265 (2010). https://doi.org/10.1007/s10384-010-0812-2

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  • DOI: https://doi.org/10.1007/s10384-010-0812-2

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