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Chronic myositis with cardiomyopathy and respiratory failure associated with mild form of organ-specific autoimmune diseases

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Abstract

We report the four patients with chronic myositis characterized by a very slow progression with cardiomyopathy and frequently with marked respiratory muscle weakness associated with other organ-specific autoimmune diseases such as primary biliary cirrhosis. The histopathology of the muscle showed many degenerative and regenerative fibers, but inflammatory-cell infiltration were minimal. The patients showed favorable response to high-dose corticosteroid treatment. Because of these clinical features, these patients are sometimes misdiagnosed as muscular dystrophy and not treated properly. It is important to distinguish this type of treatable myositis.

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Authors and Affiliations

  1. Department of Neurology, Brain Research Institute, Niigata University, Niigata City, Niigata, 951-8585, Japan

    K. Tanaka, A. Sato, K. Kasuga, M. Kanazawa, K. Yanagawa, M. Umeda, M. Tada & M. Nishizawa

  2. Department of Neurology, National Utano Hospital, Kyoto, Japan

    M. Tanaka

Authors
  1. K. Tanaka
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  2. A. Sato
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  3. K. Kasuga
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  4. M. Kanazawa
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  5. K. Yanagawa
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  6. M. Umeda
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  7. M. Tada
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  8. M. Tanaka
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  9. M. Nishizawa
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Corresponding author

Correspondence to K. Tanaka.

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Tanaka, K., Sato, A., Kasuga, K. et al. Chronic myositis with cardiomyopathy and respiratory failure associated with mild form of organ-specific autoimmune diseases. Clin Rheumatol 26, 1917–1919 (2007). https://doi.org/10.1007/s10067-007-0698-7

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  • DOI: https://doi.org/10.1007/s10067-007-0698-7

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